histocytoma (his´tōsītō´mə),

n a tumor composed of histiocytes.
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80% of these lesions were lymphoma metastases and 20% from malignant fibrous histocytoma.
The differential diagnosis of this lesion includes fibrous histiocytoma, Malignant fibrous histocytoma, synovial sarcoma, other stromal sarcomas, juxtaglomerular tumor, vascular leiomyoma, juvenile hemangioma and lobular capillary hemangioma.
Complete wide resection of the malignant fibrous histocytoma of the chest wall; expect for long survival.
Pleomorphic malignant fibrous histocytoma /undifferentiated high grade pleomorphic sarcoma.
Other aggressive myxoid tumours, including myxoid angiomyxoma and myxoid malignant fibrous histocytoma, should be considered.
Epithelioid sarcoma has many histopathologic mimics, including benign and malignant conditions, such as granuloma annulare, necrobiosis lipoidica, chronic granulomatous inflammation (especially rheumatoid nodules), fibrous histocytoma, nodular fasciitis, fibromatosis, giant cell tumor of tendon sheath, melanoma, clear-cell sarcoma of the tendon and aponeurosis (amelanotic melanoma of soft part), schwannoma, metastatic squamous cell carcinoma, metastatic adenocarcinoma (especially renal cell carcinoma), synovial sarcoma, epithelioid hemangioendothelioma, epithelioid leiomyosarcoma, and malignant extrarenal rhabdoid tumors of the soft tissue.
Differential diagnosis: Malignant fibrous histocytoma, fibrosarcoma, liposarcoma, osteosarcoma, and chondrosarcoma.
These morphological features can mimic other benign or malignant lesions, such as malignant peripheral nerve sheath tumor (MPNST), malignant mesothelioma, sarcomatoid type, monophasic synovial sarcoma, malignant fibrous histocytoma, fibrosarcoma, leiomyosarcoma, and spindle cell carcinoma.