histocompatibility


Also found in: Dictionary, Thesaurus, Encyclopedia, Wikipedia.

histocompatibility

 [his″to-kom-pat″ĭ-bil´ĭ-te]
1. the quality of a cellular or tissue graft enabling it to be accepted and functional when transplanted to another organism.
2. the degree to which two individuals are histocompatible. adj., adj histocompat´ible.

his·to·com·pat·i·bil·i·ty

(his'tō-kom-pat'i-bil'i-tē),
A state of immunologic similarity (or identity) that permits successful homograft transplantation.

histocompatibility

/his·to·com·pa·ti·bil·i·ty/ (-kom-pat″ĭ-bil´it-e) that quality of being accepted and remaining functional; said of that relationship between the genotypes of donor and host in which a graft generally will not be rejected, a relationship determined by the presence of compatible HLA antigens.histocompat´ible

histocompatibility

(hĭs′tō-kəm-păt′ə-bĭl′ĭ-tē)
n. pl. histocompatibili·ties
A state or condition in which the absence of immunologic interference permits the grafting of tissue or the transfusion of blood without rejection.

his′to·com·pat′i·ble adj.

histocompatibility

[his′tōkəmpat′ibil′itē]
Etymology: Gk, histos, tissue; L, compatibilis, agreeing
a measure of the similarity of the antigens of a donor and a recipient of transplanted tissue.

his·to·com·pat·i·bil·i·ty

(his'tō-kŏm-pat'i-bil'i-tē)
A state of immunologic similarity (or identity) that permits successful homograft transplantation.

histocompatibility

Sufficient affinity between the genetic composition (genotypes) of donor and host to allow successful tissue or organ grafting.

histocompatibility

the acceptance by a recipient of tissue transplanted from a donor, a state that is determined by histocompatability ANTIGENS.

Histocompatibility

The major histocompatibility determinants are the human leukocyte antigens (HLA) and characterize how well the patient and donor are matched.

histocompatibility

sufficient genetic similarity to permit tissue transplantation (see homograft)

his·to·com·pat·i·bil·i·ty

(his'tō-kŏm-pat'i-bil'i-tē)
State of immunologic similarity that permits successful homograft transplantation.

histocompatibility,

n the compatibility of the antigens of donor and recipient of transplanted tissue.
histocompatibility testing,
n the determination of the compatibility of the antigens of donor and recipient before tissue transplantation. Usually follows a blood typing protocol.

histocompatibility

the quality of a cellular or tissue graft enabling it to be accepted and functional when transplanted to another animal.

histocompatibility antigen
genetically determined antigens present on the cell membranes of nucleated cells of most tissues, which incite rejection when tissues are grafted to a different individual and thus determine the compatibility of tissues in transplantation. Major histocompatibility antigens exert the strongest effect on transplanted tissues, while the many minor histocompatibility antigens, such as blood group substances and the secretory alloantigen system, have a weaker, though often highly significant role in graft rejection.
histocompatibility genes
genes that code for the histocompatibility antigens.
major histocompatibility complex (MHC)
a cluster of loci on one autosomal chromosome containing the genes that code for the major histocompatibility antigens. The best studied MHC is the H2 complex of the mouse followed by the HLA (human leukocyte antigen) of humans. In other species it is further specified: the dog leukocyte antigen (DLA), the bovine leukocyte antigen (BOLA), the swine leukocyte antigen (SLA), etc.
MHC class I is a polymorphic set of transmembrane heterodimeric proteins consisting of an α chain, encoded within the MHC gene complex, associated noncovalently with β2-microglobulin expressed on nearly all nucleated cells and which form a trimeric complex with typically 9-mer peptides that are then transported and presented on the surface of the cells and serve as targets for cytotoxic T lymphocytes (CTL or Tc), CD8 cells. A major defense mechanism against viral infections.
MHC class II is a polymorphic set of transmembrane heterodimeric proteins that consist of noncovalently associated α and β proteins, both encoded within the MHC gene complex. They form a trimeric complex with antigenic peptides, which may be up to 35-mers, in antigen presenting cells which are then transported to the surface of the cell for presentation to T helper lymphocytes. The basis for all T lymphocyte responses.
References in periodicals archive ?
The patent, entitled "MHCclass II Beta-Chain/Peptide Complexes Useful in Ameliorating Deleterious Immune Responses," covers the binding of the beta-chain of the major histocompatibility complex class II molecule with peptides associated with more than 30 known autoimmune diseases.
She has been a lecturer and Professor regarding pathology issues for over twenty-five years and has published numerous papers related to histocompatibility, antibody screening and allograft transplant.
The study, which was published in Science Translational Medicine, detailed how researchers identified two specific single-nucleotide polymorphisms, also called SNPs, within the major histocompatibility complex in human DNA that are markers for either acute GVHD or disease-free survival.
of Colorado, Boulder) simplifies the explanations presented in immunology texts by providing undergraduate and graduate students with 15 lectures that introduce components of the immune system and show how they interact in terms of the big picture, including B cells and antibodies, antigen presentation, T cells in action, secondary lymphoid organs and lymphocyte trafficking, tolerance induction and MHC (major histocompatibility complex proteins) restriction, the AIDS virus, autoimmune diseases, and allergies.
The 31 contributions collected describe immunoinformatic databases and their applications for search and mapping of immune system responses, defining and classifying human leukocyte antigen supertypes, predicting peptide-major histocompatibility complex binding, and predicting other properties of immune systems.
The San Nicolas Island foxes (Urocyon littoralis dickeyi) vary considerably in the genes coding for immune system compounds known collectively as the major histocompatibility complex (MHC), report Andres Aguilar of the University of California, Santa Cruz and his colleagues.
ASHI received deeming authority as an accrediting organization for clinical laboratories under the Clinical Laboratory Improvement Amendments of 1988 (CLIA) for the CLIA specialty of Histocompatibility and the subspecialty ABO/Rh.
A team of Australian researchers used a genetic test to look for variants of the proteins that make up the part of the immune system called the major histocompatibility complex.
The society represents the interests of transplant professionals in the areas of cardiology, hepatology, pulmonology, nephrology, surgery, pediatrics, immunology, histocompatibility and infectious disease.
Moreover, when Orth and his colleagues analyzed the tissue types of the rabbits, they found that most of those whose warts turned malignant had a particular type of major histocompatibility complex (MHC) protein on their cells.
Xencor's ImmunoFilter tools were developed based on a proprietary immunochemical data set of peptide agretope binding to class II major histocompatibility complex ("MHC") proteins, a key determinant of recognition of antigens by the immune system.