histocompatibility


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histocompatibility

 [his″to-kom-pat″ĭ-bil´ĭ-te]
1. the quality of a cellular or tissue graft enabling it to be accepted and functional when transplanted to another organism.
2. the degree to which two individuals are histocompatible. adj., adj histocompat´ible.

his·to·com·pat·i·bil·i·ty

(his'tō-kom-pat'i-bil'i-tē),
A state of immunologic similarity (or identity) that permits successful homograft transplantation.

histocompatibility

/his·to·com·pa·ti·bil·i·ty/ (-kom-pat″ĭ-bil´it-e) that quality of being accepted and remaining functional; said of that relationship between the genotypes of donor and host in which a graft generally will not be rejected, a relationship determined by the presence of compatible HLA antigens.histocompat´ible

histocompatibility

(hĭs′tō-kəm-păt′ə-bĭl′ĭ-tē)
n. pl. histocompatibili·ties
A state or condition in which the absence of immunologic interference permits the grafting of tissue or the transfusion of blood without rejection.

his′to·com·pat′i·ble adj.

histocompatibility

[his′tōkəmpat′ibil′itē]
Etymology: Gk, histos, tissue; L, compatibilis, agreeing
a measure of the similarity of the antigens of a donor and a recipient of transplanted tissue.

his·to·com·pat·i·bil·i·ty

(his'tō-kŏm-pat'i-bil'i-tē)
A state of immunologic similarity (or identity) that permits successful homograft transplantation.

histocompatibility

Sufficient affinity between the genetic composition (genotypes) of donor and host to allow successful tissue or organ grafting.

histocompatibility

the acceptance by a recipient of tissue transplanted from a donor, a state that is determined by histocompatability ANTIGENS.

Histocompatibility

The major histocompatibility determinants are the human leukocyte antigens (HLA) and characterize how well the patient and donor are matched.

histocompatibility

sufficient genetic similarity to permit tissue transplantation (see homograft)

his·to·com·pat·i·bil·i·ty

(his'tō-kŏm-pat'i-bil'i-tē)
State of immunologic similarity that permits successful homograft transplantation.

histocompatibility,

n the compatibility of the antigens of donor and recipient of transplanted tissue.
histocompatibility testing,
n the determination of the compatibility of the antigens of donor and recipient before tissue transplantation. Usually follows a blood typing protocol.

histocompatibility

the quality of a cellular or tissue graft enabling it to be accepted and functional when transplanted to another animal.

histocompatibility antigen
genetically determined antigens present on the cell membranes of nucleated cells of most tissues, which incite rejection when tissues are grafted to a different individual and thus determine the compatibility of tissues in transplantation. Major histocompatibility antigens exert the strongest effect on transplanted tissues, while the many minor histocompatibility antigens, such as blood group substances and the secretory alloantigen system, have a weaker, though often highly significant role in graft rejection.
histocompatibility genes
genes that code for the histocompatibility antigens.
major histocompatibility complex (MHC)
a cluster of loci on one autosomal chromosome containing the genes that code for the major histocompatibility antigens. The best studied MHC is the H2 complex of the mouse followed by the HLA (human leukocyte antigen) of humans. In other species it is further specified: the dog leukocyte antigen (DLA), the bovine leukocyte antigen (BOLA), the swine leukocyte antigen (SLA), etc.
MHC class I is a polymorphic set of transmembrane heterodimeric proteins consisting of an α chain, encoded within the MHC gene complex, associated noncovalently with β2-microglobulin expressed on nearly all nucleated cells and which form a trimeric complex with typically 9-mer peptides that are then transported and presented on the surface of the cells and serve as targets for cytotoxic T lymphocytes (CTL or Tc), CD8 cells. A major defense mechanism against viral infections.
MHC class II is a polymorphic set of transmembrane heterodimeric proteins that consist of noncovalently associated α and β proteins, both encoded within the MHC gene complex. They form a trimeric complex with antigenic peptides, which may be up to 35-mers, in antigen presenting cells which are then transported to the surface of the cell for presentation to T helper lymphocytes. The basis for all T lymphocyte responses.
References in periodicals archive ?
Our results confirm the strong role of the major histocompatibility complex genes in MS, and provide a definitive statement that no other region of the genome harbors a gene with a similar overall influence on MS genetics," Dr.
Lu LY, Ding DZ, Fici D, et al: Molecular analysis of the major histocompatibility complex allelic associations with systemic lupus erythematosus in Taiwan.
Identity of hybrid-derived historical groups within the Cnemidophorus tesselatus complex of parthenogenetic lizards determined through histocompatibility and karyological techniques.
We have learned some exciting things and find the ASHI contingent to be an important confluence of the histocompatibility and immunogenetics thought leaders with which to share this information.
This year's volume contains 26 articles on such topics as the genetic analysis of hypoxia tolerance and susceptibility in Drosophila and humans, cellular assays for drug discovery in genetic disorders of intracellular trafficking, major histocompatibility complex genomics and human disease, translational genetics for the diagnosis of human disorders of sex development, communicating genetic risk information for common disorders in the era of genomic medicine, and the role of patient advocacy organizations in shaping genomic science.
The patent, expiring in March 2026, also covers the use of bispecific antibodies that target CD74, the major histocompatibility complex (MHC) class-II invariant chain, Ii, of immune cells, and CD20 to form a vaccine complex.
The allowed claims cover the use of bispecific antibodies targeting CD74, the major histocompatibility complex (MHC) class-II invariant chain, Ii, of immune cells and CD20 to form a vaccine complex.
Abouljoud, MD, Henry Ford Hospital; Region 11 Councillor-David Shaffer, MD, PhD, Vanderbilt University Medical Center; Histocompatibility Representative-John Gerlach, PhD, D(ABHI), Immunohematology and Serology, Michigan State University; OPO Representative-Susan A.
The researchers looked at a protein called Major Histocompatibility Complex type 1 (MHC type I).
The alphabetized content ranges from historical figures in the field to molecular structures of recently characterized cytokines, the major histocompatibility complex molecules, imunoglobulins, and molecules of related interest to immunologists.
The researchers scanned the genome of cytomegalovirus and found a microRNA that targets a gene called major histocompatibility complex class I-related chain B (MICB).