histiocytic lesion

histiocytic lesion

An aggregate of histiocytes, which may be benign, indeterminant, or malignant in proliferative potential; to reduce confusion, it has been suggested that histiocytoses be subdivided into different categories
Histiocytic lesions-Behavior classification  
Benign
Familial histiocytosis with eosinophilia A chronic disease of infants with recurring bacterial infections, diarrhea, eczema, alopecia, associated with immunodeficiency
Sinus histiocytosis with massive lymphadenopathy Rosai-Dorfman disease A disease most common in adolescent blacks with massive cervical lymphadenopathy as well as enlargement of extranodal (orbit, skin, bone, salivary gland, testis) lymphoid tissues
Virus-associated hemophagocytic syndrome A condition induced by viral infections, often accompanied by abnormal liver function tests, coagulation assays and pancytopenia Pathology Histiocyte hyperplasia, hemophagocytosis and replacement of native bone marrow elements
Intermediate
Histiocytosis X, aka Langerhans' cell histiocytosis, see there.
Reactive hemophagocytic syndrome, see there.
Malignant
Histiocytic medullary reticulosis see there.
Histiocytic proliferations, eg—acute monocytic leukemia (FAB M3), histiocytic lymphoma see there, malignant histiocytosis–see there.
References in periodicals archive ?
CD68 may be used to rule out a histiocytic lesion, as abundant xanthomatous change within the schwannoma may introduce that possibility into the differential diagnosis.
1) It is a rare, benign, non-Langerhans histiocytic lesion that typically arises in the head and neck, trunk, upper extremities, and lower extremities.
The differential diagnosis of JXG should include other histiocytic lesions, Rosai-Dorfman disease, and infectious causes.
Juvenile xanthogranuloma (JXG) is a benign, non-Langerhans cell histiocytic lesion that generally affects infants and children.
Thus, we consider that any histiocytic lesion with admixed prominent eosinophilic infiltrate requires immunohistochemical studies to rule out LCH.
7) Soft tissue RDD presentation is with non-specific features, leading to misdiagnosis as benign inflammatory and fibro histiocytic lesions as well as lymphoma and malignant fibrous histiocytoma.