hirudin


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Related to hirudin: Lepirudin, Bivalirudin, Desirudin

hirudin

 [hĭ-roo´din]
the active principle of the buccal secretion of leeches; it prevents clotting of the blood. A product made with recombinant technology is used as an anticoagulant.

hir·u·din

(hir'ū-din),
An antithrombin substance extracted from the salivary glands of the leech that has the property of preventing coagulation of the blood.
[L. hirudo, leech]

hirudin

/hi·ru·din/ (hĭ-rldbomacd´in) the active principle of the buccal secretion of leeches; it prevents coagulation by acting as an antithrombin.

hirudin

(hîr-o͞od′n, hîr′ə-dən, -yə-)
n.
A substance secreted by the buccal glands of leeches, capable of preventing coagulation by inactivating thrombin and used in medicine as an anticoagulant.

hirudin

Hematology The most potent known inhibitor of thrombin, produced by the medicinal leech, Hirudo medicinalis

hir·u·din

(hir-ū'din)
An antithrombin substance extracted from the salivary glands of the leech that has the property of preventing coagulation of the blood.
[L. hirudo, leech]

hirudin

A substance secreted by the salivary glands of leeches to prevent blood coagulation so that they can continue to feed on blood. The leeches are, of course, unaware that their hirudin acts by binding directly to thrombin molecules thus preventing them from converting soluble fibrinogen to fibrin. Hirudin has been found capable of preventing restenosis after coronary angioplasty.

hirudin

the active principle of the buccal secretion of leeches; it prevents clotting of the blood.
References in periodicals archive ?
Some of the most unusual words played in the final were:NEONATES - scoring 71 to win Paul Gallen the final - it means a newborn child, particularly in the first week of life VAUNTIER - scoring 72 points and meaning to be more boastful HIRUDIN - scoring 61, it is an anticoagulent in the mouth of leeches ALANNAHS - scoring 32 it is an Irish word meaning my children.
A neonate is a newborn child and hirudin is an anticoagulant found in the mouths of leeches.
As a bivalent DTI, bivalirudin is a short synthetic peptide that consists of the N-terminal and C-terminal active peptide domains of hirudin joined by a linker.
If the platelet count drops below 100 000 cells/[MU]l or 50% of its initial value, heparin should be stopped and substituted with a hirudin derivative.
Probing the hirudin thrombin interaction by incorporation of noncoded amino acids and molecular dynamics simulation.
Lepirudin is a recombinant form of Hirudin, an anticoagulant extracted from leeches.
HIT tedavisinde secilebilecek antikoagulanlar; bir heparinoid olan danaparoid, geri donusumsuz direk trombin inhibitoru rekombinant hirudin olan lepirudin, geri donu sumlu direk trombin inhibitorleri bivalirudin, argatroban ve fondaparinuxtur [6].
Previously unsuspected in the pathogenesis of MS, dysregulation of coagulation was further explored by administration of hirudin and recombinant activated protein C to SJL/J mice with EAE, resulting in amelioration of the disease.
11) A particularly compelling hypothesis is supported by animal models in which full anticoagulation with the noncomplement activating anticoagulants hirudin or fondaparinux cannot prevent pregnancy loss or thrombosis; however, sub-anticoagulant doses of heparin, complement deficiency, or complement inactivation by other mechanisms are able to do so.
The transplant was completed in a three-hour procedure without complications, thanks largely to bivalirudin, the synthetic form of hirudin, a powerful anticoagulant produced by the salivary glands of medicinal leeches.
Heparine bagli trombositopeni oykusu olan hastalarda antikoagulasyon icin hirudin (Refludan), bivalirudin (Hirulog), and argatroban kullanilmaktadir.
Dabigatran inhibits both clot -bound and fluid phase thrombin in vitro: Effects compared to heparin and hirudin.