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hinge region

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hinge region
n.
1. The portion of a crystalline form of tRNA that deforms to an L shape under electron microscopy.
2. A short sequence of amino acids that lies at the base of each of the heavy chain regions of an immunoglobin and facilitates flexible movement of the molecule.
hinge region
a proline-rich portion of an immunoglobulin heavy chain between the Fc and Fab regions that confers mobility on the two Fab arms of the antibody molecule thereby allowing it to combine better with the two epitopes.


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