high-molecular-weight kininogen

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High-molecular-weight kininogen

See Fitzgerald Factor.

high-molecular-weight kininogen



A protein kininogen that is one of the early participants of the intrinsic pathway of coagulation and functions as a cofactor for activating kallikrein and the Hageman factor.
See: coagulation factor under factor
References in periodicals archive ?
In affected patients, "activation of the kallikreinkinin cascade leads to uncontrolled generation of plasma kallikrein and consequent proteolysis of high-molecular-weight kininogen.
Pharmacodynamic assessments showed that lanadelumab inhibited kallikrein in a linear, dose-dependent manner, and the two higher doses reduced levels of cleaved high-molecular-weight kininogen to those reported in healthy controls.

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