high-grade lymphoma

high-grade lymphoma

Oncology An aggressive lymphoma that responds poorly to chemotherapy and comprises 20% of lymphomas  Prognosis HGLs have a mean survival of < 1 yr without therapy. See Lymphoma.
References in periodicals archive ?
Transformation to a high-grade lymphoma occurs in 25 to 35% of patients.
Transformation of lymphoplasmacytic lymphoma to high-grade lymphoma usually portends an adverse prognosis, and there is no established treatment regimen.
4) Intermediate and high-grade lymphoma classification is a risk factor for CNS involvement in NHL.
Conlan et al (26) found that patients with high-grade lymphoma had a lower median Hb value and a higher prevalence of anemia than patients with intermediate-grade and low-grade lymphomas.
While some intermediate-grade and high-grade lymphoma patients may be cured by chemotherapy, low-grade lymphoma is generally incurable.
In addition, it is relatively common for IPSID to progress to a high-grade lymphoma indistinguishable from DLBCL.
Complete remission and sometimes long-term disease-free survival may be obtained with standard combination chemotherapy designed for high-grade lymphoma.
The Phase I portion of this multiple-dose trial was conducted in 20 patients with low, intermediate or high-grade lymphoma.
The overall complete and partial response rate to the therapy has been 45%; 56% in low-grade lymphoma, 31% in intermediate-grade lymphoma and 47% in high-grade lymphoma.
Relationship between high-grade lymphoma and low-grade B-cell mucosa-associated lymphoid tissue lymphoma (MALToma) of the stomach.
The Phase I portion of this multiple-dose trial was conducted in 17 patients with low, intermediate or high-grade lymphoma.