Hidradenocarcinoma originates in the eccrine glands located in sun-exposed areas and accounts for approximately 6% of malignant eccrine tumors and <0.
The overall findings suggested the diagnosis of hidradenocarcinoma.
Hernanadez perez E, Cestoni- Parducci R: Nodular hidradenoma & Hidradenocarcinoma
10yr review J Am Acad Dermatol 1985: 12: 15-20.
A number of carcinomas may display predominant clear cells in the skin, including squamous cell carcinoma (Figure 3, A) and adnexal carcinomas, such as tricholemmal carcinoma, sebaceous carcinoma, and hidradenocarcinoma
1) An MEA is also known as a malignant clear-cell hidradenoma, clear-cell hidradenocarcinoma
, and malignant nodular hidradenoma.
HISTOLOGICAL TYPES OF HIDRADENOMA: Most cases of hidradenocarcinoma
arise de novo.
No cases (0%) of hidradenocarcinoma
papilliferum, porocarcinoma, eccrine carcinoma, cylindrocarcinoma, hidradenocarcinoma
, malignant chondroid syringoma, mucinous carcinoma, and adenocarcinoma of mammary-like glands were found.
The more common subtypes include microcystic adnexal carcinoma, eccrine porocarcinoma, and hidradenocarcinoma
Several additional histologic types of SGC were examined in this study, (18) including apocrine, hidradenocarcinoma
, mucinous, and basaloid carcinomas, which were not included in our study.
I have not seen an example of ACCCC showing areas of ductal differentiation or a hybrid lesion showing areas of ACCCC and classic hidradenocarcinoma
to support that association.
The prognosis for survival with newly diagnosed nodular hidradenocarcinoma
is generally poor and, notably, the 5-year disease-free survival rate is less than 30%.
Similarly, porocarcinoma and hidradenocarcinoma
appear to be closely related neoplasms, which present several overlapping histologic features, including solid-cystic pattern, eosinophilic and clear cells, central necrosis of tumor lobules, and ductal structures.