hexosaminidase


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hex·os·a·min·i·dase

(hek'sōs-ă-min'i-dās),
General term for enzymes hydrolyzing N-acetylhexose (for example, N-acetylglucosamine) residues from gangliosidelike oligosaccharides. At least four specific enzymes carrying out this type of reaction are known: α-N-acetyl-d-galactosaminidase, α-N-acetyl-d-glucosaminidase, β-N-acetyl-d-hexosaminidase, and β-N-acetyl-d-galactosaminidase, each being specific for the configuration and type of sugar included in the name.

hexosaminidase

/hex·os·amin·i·dase/ (hek″sōs-ah-min´ĭ-dās)
1. any of the enzymes that cleave hexosamines or acetylated hexosamines from gangliosides or other glycosides.
2. a specific hexosaminidase acting on keratan sulfate and ganglioside GM2 and related compounds.

hex·os·a·min·i·dase

(heks-ōs'ă-min'i-dās)
General term for enzymes cleaving N-acetylhexose residues from gangliosidelike oligosaccharides.

hexosaminidase

an enzyme that catalyzes the cleavage of hexose from ganglioside GM2. Occurs in two forms, A and B. Deficiency occurs in GM2gangliosidosis of dogs, cats and pigs.
References in periodicals archive ?
Pichiapastoris GS115 recombinant hexosaminidase production
These results might agree with dimer association description during native hexosaminidase A crystallization [15].
Geiger B, Arnon R, Sandhoff IK Immunochemical and Biochemical Investigation of Hexosaminidase S, The American Journal of Human Genetics, 29: 508-522, 1977.
IgE-mediated activation caused a rapid release of [beta]- hexosaminidase in basophilic cells and mast cells (Fig.
M2] gangliosidosis B1 variant: biochemical and molecular characterization of hexosaminidase A.
Expression of hexosaminidase isoenzymes in childhood leukemia.
In preliminary experiments with other lysosomal enzymes, such as hexosaminidase and [beta]-galactosidase, we observed that activities on filter-paper cards were stable over a period of several weeks when stored dry at room temperature.
Detection of heterozygotes and homozygotes by serum hexosaminidase assay.
Standardization of leukocytes for Tay-Sachs hexosaminidase assay [Abstract].
Automated determination of serum hexosaminidase A by pH inactivation for determination of Tay-Sachs disease heterozygotes.
The subunit and polypeptide structure of hexosaminidase from human placenta.