E values of hexosamine
in different groups of rabbits were shown in Table 2, Fig.
Hyperglycemia induces PAI-1 gene expression in adipose tissue by activation of the hexosamine
Palmitate-induced activation of the hexosamine
pathway in human myotubes.
1C) and supported cleavage with charge retention on the hexosamine
16) In addition, alterations in the sorbitol, hexosamine
, and protein kinase C pathways are also implicated and are believed to damage Schwann cells, causing neuropathy.
Srivastava, Alkaline phosphatase, total protein, protein bound hexoses and hexosamine
changes in serum and wound fluids in surgically induced subcutaneous wounds in buffalo calves, Acta Vet Academiss Scientiarum Hugarica Tonus, 26:268-74 (1976).
Hyperglycemia-mediated activation of the hexosamine
biosynthetic pathway results in myocardial apoptosis.
The Collagen, Hyxdroxyproline, Hexosamine
and Elastin content of the healing tissue were determined.
pathway regulates the plasminogen activator inhibitor-1 gene promoter and Sp1 transcriptional activation through protein kinase C-[beta]l and -[delta]*.
It has been suggested that the hexosamine
biosynthetic pathway is involved in the pathogenesis of insulin resistance in patients with type 2 diabetes mellitus because the activity of the rate-limiting enzyme of this pathway, glutamine:fructose-6-phosphate amidotransferase (EC 2.
It is well established that glucose can induce insulin resistance of the glucose transport system in adipocytes, through a mechanism that involves increased metabolism of glucose through the hexosamine
signaling pathway (Marshall et al.
Regions in which the hexosamine
units are acetylated remain (almost) unmodified and consist of disaccharide repeats with GlcA, whereas regions with deacetylated hexosamine
units become highly sulfated and exist as disaccharide repeats with iduronate.