Recent progress in DNA polymerase engineering has successfully isolated variants with expanded substrate spectra capable of efficiently synthesising hexitol
nucleic acids (HNA) from DNA templates, and capable of synthesising DNA from HNA templates.
74] Chewing gum also increases secretion of saliva and pancreatic juices, and a recent study proposed that sorbitol and hexitol
found in sugar-free gum may also play a role in the reduction of postoperative ileus.
14]C with species of fungi known to contain large amounts of mannitol have generally shown that the hexitol
is a primary product of heterotrophic assimilation (LEWIS, 1971).
Production of the Hexitol
d-Mannitol by cryptococcus neoformans in vitro and in rabbits with experimental meningitis.
Most dietary sugars and polyols are structurally based on a six-carbon hexose or hexitol
Investigation on the mechanism by fructose, hexitols
and other compounds regulate the translocation of glucokinase in rat hepatocytes.
Recently, it has been proposed that hexitols
present in sugarless chewing gums might also be playing a role in the amelioration of POI because these are known to cause gastrointestinal symptoms such as gas, bloating, and abdominal cramps in a dose-dependent manner.
The patent is named 'Method of Synthesis of Substituted Hexitols
Such as Dianydrogalactitol' and has a patent term that lasts until 2030.
In addition, sugar free chewing gum that contains the artificial sweetener sorbitol and other hexitols
might be having side effects such as bloating, gas, and abdominal cramps.
Because it is difficult to exclude the presence of other six-carbon polyols solely on the retention times on the HPLC column, we used 1H- and 13C-NMR, which together can distinguish the isomeric hexitols
, to further analyze the ethanol-soluble fraction.