heterophile antibody test


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heterophile antibody test

A laboratory test for infectious mononucleosis.
References in periodicals archive ?
A heterophile antibody test was negative, however, as were EBV titers.
A heterophile antibody test yielded a positive result the day after admission, and a clinical diagnosis of infectious mononucleosis was confirmed 7 days later with positive Epstein–Barr virus (EBV) serology-positive viral capsid antigen immunoglobulin M, negative viral capsid antigen immunoglobulin G (IgG), and EBV nuclear antigen IgG.
Blood cultures, monospot test (a form of the heterophile antibody test for infectious mononucleosis due to Epstein-Barr virus), and serology for hepatitis viruses were all negative.
The sharing of antigens between rickettsia and proteus is the basis of this heterophile antibody test.
To avoid this, serum specimens should be mixed with staphylococcal protein A to adsorb the rheumatoid factor--an unnecessary complication with the existence of the heterophile antibody test.
The polymerase chain reaction (PCR) assay for Epstein-Barr virus DNA is more sensitive than the heterophile antibody test in children, is highly specific, but is also expensive (SOR: C, based on validating cohort study).
3-5] Second, the heterophile antibody test used in this study had a sensitivity of only 78% for IM.
The assumption was made that a heterophile antibody test was initially requested by the patient's physician in response to presenting clinical signs and symptoms suggestive of an infectious mononucleosis-type illness.
3) He also had the typical clinical picture, hematologic changes, and serologic response of infectious mononucleosis, ie, a young adult with sore throat, malaise, fatigue, headache, pharyngitis, abnormal liver function tests, a relative and absolute lymphocytosis with an elevated percentage of atypical lymphocytes, and a positive heterophile antibody test.
The classic diagnostic approach is to get a CBC and heterophile antibody test such as a Monospot.
The diagnosis relies on atypical lymphocytes which resemble monocytes or on heterophile antibody tests which assess agglutination with sheep, guinea pig and horse red cells.