heterophile antibodies

heterophile antibodies

human antibodies capable of binding to animal immunoglobulins and possibly of interfering with reaction of animal-derived antibodies and analyte, which comprise all immunoassays. The three groups of heterophile antibodies are polyspecific antibodies, antiimmunoglobulin antibodies, and high-specificity high-affinity antibodies against antigens from animal species. In clinical practice, the most important significance of heterophile antibodies is their use in diagnosing infectious mononucleosis.
References in periodicals archive ?
Heterophile antibodies are human antibodies with the ability to bind to animal immunoglobulins, thereby possibly interfering with the interaction between animal-derived antibodies and the antigen [hCG in our discussion], which are components of all immunoassays.
determination latex heterophile antibodies associated with infectious mononucleosis.
For a final investigation of the possibility of heterophile antibodies, the HBT treatment and Roche human anti-mouse antibodies procedure were done on a separate patient sample (Table 5).
Heterophile antibodies, specific auto-antibodies or rheumatoid factor can interfere in numerous immunoassays, by binding to reagent antibodies or particles, causing falsely increased or decreased results (Fig.
Other non-EBV infections and immunologic reactions induce heterophile antibodies.
Publications regarding the lack of analytical specificity owing to confounders, such as heterophile antibodies and rheumatoid factor, date back to the early 2000s after the initial introduction of cardiac troponin assays.
2,3) Other interferences fall into the category of species-nonspecific heterophile antibodies.
A variety of methods for pretreating specimens to inactivate heterophile antibodies exist, but all are too expensive and impractical for general use.
Another source of false-positive prolactin results is interference from heterophile antibodies.
In addition, humans naturally produce human anti-human immunoglobulin antibodies or heterophile antibodies that can cross-react with and bind animal antibodies.
Evaluation of 12 commercial tests for detection of Epstein-Barr virus-specific and heterophile antibodies.
We investigated the frequency of such occurrences, whether the results obtained with diluted or undiluted samples were more consistent with liquid chromatographytandem mass spectrometry (LCMS/MS) [1] results, and whether the cause of the nonlinear dilution might be due to interfering heterophile antibodies.