heterophile


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Related to heterophile: heterophile antigen

heterophil

 [het´er-o-fil″]
1. a finely granular polymorphonuclear leukocyte represented by neutrophils in human, but characterized in other mammals by granules that have variable sizes and staining characteristics.
2. heterophilic (def. 1).
heterophil antibody a characteristic antibody found with infectious mononucleosis, demonstrated in 90 to 95 per cent of adolescents and adults and 50 per cent of children with the disease. It declines in titer after acute illness has resolved but may be detectable for up to 9 months after disease onset.

het·er·o·phil

, heterophile (het'ĕr-ō-fil, -fīl),
1. Pertaining to heterogenetic or cross-reacting antigens occurring in different species or to antibodies directed against such antigens.
2. The neutrophilic leukocyte in humans; in some animals, the granules vary in size and staining reaction.
[hetero- + G. philos, fond]

heterophile

het·er·o·phil

, heterophile (het'ĕr-ō-fil, -fīl)
1. The neutrophilic leukocyte.
2. Pertaining to heterogenetic antigens occurring in different species or to antibodies directed against such antigens.
[hetero- + G. philos, fond]
References in periodicals archive ?
sup][2] However, the Hoagland criteria state that in patients presenting with clinically suspected infectious mononucleosis, the diagnosis should be confirmed using the heterophile antibody (monospot) test.
Clinicians should be aware of the characteristics of cardiac troponin assay performance that may be of a general analytical nature, such as interference in the assay from heterophile antibodies (4), as well as those related to specific features of cardiac troponin biology or the assay used.
Although heterophile antibody test is not sensitive, the positive result can reject the need for further investigation.
The monospot test is a latex assay that causes hemagglutination of horse RBCs in the presence of heterophile antibodies characteristic of infectious mononucleosis.
Phantoms in the assay tube: heterophile antibody interferences in serum thyroglobulin Assays.
Following a positive heterophile antibody test for Epstein-Barr virus, he was diagnosed with mononucleosis.
His heterophile agglutination titer was 1:128 and his WBC count was 12,500.
The diagnosis relies on atypical lymphocytes which resemble monocytes or on heterophile antibody tests which assess agglutination with sheep, guinea pig and horse red cells.
They can be heterophile (nonspecific) antibodies, human anti-animal antibodies or autoantibodies to TSH, T4 or T3.
Rapid tests for HIV and influenza were negative, as were tests for acute hepatitis and heterophile antibodies.
The majority of interferences are eliminated by recentrifuging specimens, performing dilution studies, or using heterophile antibody blocking tubes.
18) Without liver biopsy, EBV infection can be diagnosed based on clinical suspicion and proper laboratory data including EBV IgM antibody, positive monospot and heterophile antibody testing.