herpes simplex encephalitis


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her·pes sim·plex en·ceph·a·li·tis

the most common acute encephalitis, caused by HSV-1; affects people of any age; preferentially involves the inferomedial portions of the temporal lobe and the orbital portions of the frontal lobes; pathologically, severe hemorrhagic necrosis is present along with, in the acute stages, intranuclear eosinophilic inclusion bodies in the neurons and glial cells.

herpes simplex encephalitis

a necrotizing inflammation of the brain that follows an infection with herpes simplex virus. It is a common acute form of encephalitis and is similar to other viral encephalitis infections. Repeated seizures occur early in the course, and there is severe hemorrhagic necrosis. Affected areas of the brain are usually the orbital portions of the frontal lobes and the inferomedial portions of the temporal lobe. Persons of any age may be infected, but cerebral sequelae (caused by HSV2) are more likely to occur in infants. The mortality rate varies, but even desperately ill patients may recover completely.
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Herpes simplex encephalitis
References in periodicals archive ?
Rapid diagnosis of herpes simplex encephalitis by nested polymerase chain reaction assay of cerebrospinal fluid.
Herpes simplex encephalitis is the most frequently occurring type of viral severe encephalitis [1].
Diffusion-weighted imaging and apparent diffusion coefficient evaluation of herpes simplex encephalitis and Japanese encephalitis.
Prognostic value of intrathecal antibody production and DNA viral load in cerebrospinal fluid of patients with herpes simplex encephalitis.
Unlike in herpes simplex encephalitis, where well over 90% of biopsyproven affected patients display intracranial neuroimaging abnormalities, that's true for only about half of patients with WNV encephalitis, and even then special MRI techniques such as flare or fast-spin often are required.
This practice has been adopted irrespective of the likelihood of the patient having herpes simplex encephalitis.
Herpes simplex encephalitis and the immunocompromised: a clinical and autopsy study of HSE in the settings of cancer and human immunodeficiency virus-type 1 infection.
Relapse of herpes simplex encephalitis after conventional acyclovir therapy.
Earlier in the year, the company received FDA approval for acyclovir injection for the treatment of herpes simplex one and two, herpes simplex encephalitis and varicella, and approval of a third generic injectable drug is anticipated in the near future.
A presumptive diagnosis of herpes simplex encephalitis (HSE) was made on the basis of serological and MRI findings; empirical treatment with intravenous acyclovir 750 mg eight hourly was initiated.
Herpes simplex encephalitis is believed to account for 10%-20% of cases (12), but pathogen identification is not always possible (16).
Although herpes simplex encephalitis and other CNS infections can affect neurodevelopment and cognitive function, the authors said this was the first study to follow up long-term behavioral outcomes or ADHD-related symptoms in children after an enterovirus 71 (EV71) CNS infection.