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herpes simplex encephalitis |
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herpes simplex encephalitis, a necrotizing inflammation of the brain that follows an infection with herpes simplex virus. It is a common acute form of encephalitis and is similar to other viral encephalitis infections. Repeated seizures occur early in the course, and there is severe hemorrhagic necrosis. Affected areas of the brain are usually the orbital portions of the frontal lobes and the inferomedial portions of the temporal lobe. Persons of any age may be infected, but cerebral sequelae (caused by HSV2) are more likely to occur in infants. The mortality rate varies, but even desperately ill patients may recover completely. How to thank TFD for its existence? Tell a friend about us, add a link to this page, add the site to iGoogle, or visit webmaster's page for free fun content. |
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Survivors of herpes simplex encephalitis have a shorter life expectancy (12,13), and to a lesser extent, so have patients with other viral encephalitides (13). The same two proteins, always occurring together, also have been found in a majority of patients with herpes simplex encephalitis and Creutzfeldt-Jakob disease, as well as in some patients with Parkinson's disease and multiple sclerosis, although sample sizes are still relatively small. Earlier in the year, the company received FDA approval for acyclovir injection for the treatment of herpes simplex one and two, herpes simplex encephalitis and varicella, and approval of a third generic injectable drug is anticipated in the near future. |
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