hereditary nonpolyposis colorectal cancer

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hereditary nonpolyposis colorectal cancer

an autosomal dominant predisposition to early-onset colorectal cancer in the absence of adenomatosis. The disease phenotype may be limited to the colorectum (Lynch syndrome I) or coexist with extracolonic tumors such as endometrial or gastric cancer among others (Lynch syndrome II). The genetic basis is in one of several genes responsible for DNA mismatch repair; in over 90% of cases, the mutation is one of two genes: MSH2 and MLH1.

he·red·i·tar·y non·pol·y·po·sis co·lo·rec·tal can·cer

(hĕr-ed'i-tar-ē non'pol-i-pō'sis kō'lŏr-ek'tăl kan'sĕr)
An autosomal dominant predisposition to cancer of the colon and rectum.
References in periodicals archive ?
Microsatellite instability with mutations in MSH2, MSH6, MLHl, and PMS2 also has been observed in 20% of sporadic endometrial cancers, as well as women with Lynch syndrome (also known as hereditary nonpolyposis colorectal cancer syndrome) (J.
Immunohistochemistry versus microsatellite instability testing for screening colorectal cancer patients at risk for hereditary nonpolyposis colorectal cancer syndrome.
26, 2014 /PRNewswire/ -- Quest Diagnostics(NYSE: DGX), the world's leading provider of diagnostic information services, today announced new pathology and blood test offerings to help identify and assess an individual's risk of Lynch syndrome, also known as hereditary nonpolyposis colorectal cancer (HNPCC), an inherited genetic disorder that significantly increases the risk of colorectal and other cancers.
5) Unlike familial adenomatous polyposis, which manifests as hundreds to thousands of polyps in the large intestine, the syndrome described by Lynch is usually characterized by relatively few polyps, hence the term hereditary nonpolyposis colorectal cancer.
Gastrointestinal polyposis syndromes and hereditary nonpolyposis colorectal cancer.
Patients had to have no prior history of resection, no prior diagnosis of inflammatory bowel disease, and no familial adenomatous polyposis or hereditary nonpolyposis colorectal cancer.
Chapter topics include the effect of adjuvant therapy on surgical treatment of rectal cancer, three-dimensional endorectal ultrasonography in rectal cancer staging, transanal endoscopic microsurgery in early rectal cancer, and germline and somatic mutations in colorectal cancers from patients with hereditary nonpolyposis colorectal cancer.
Cancer risk in families with hereditary nonpolyposis colorectal cancer diagnosed by mutation analysis.
Three of the most common and best understood are the Hereditary Nonpolyposis Colorectal Cancer (HNPCC), Familial Adenomatous Polyposis (FAP), and MYH-Associated Polyposis (MAP) syndromes.
Abnormalities of lectin histochemistry in familial polyposis coli and hereditary nonpolyposis colorectal cancer.
2003), a process known to correct replication errors; deficiencies in this pathway have been linked to the development of hereditary nonpolyposis colorectal cancer (Heinen et al.
Twenty-seven labs said they test for Alzheimer's disease, breast cancer, or hereditary nonpolyposis colorectal cancer.

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