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hereditary nonpolyposis colon cancer

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hereditary nonpolyposis colon cancer
Lynch I syndrome Oncology A relatively distinct AD form of cancer that may account for 5-10% of all colorectal CA Clinical Family Hx of colorectal CA at relatively young age, primarily of proximal colon, tendency toward multiple primary tumors; HNPCC may be ssociated with extracolonic tumors–eg, of endometrium Diagnosis Amsterdam criteria. See Amsterdam criteria, Colorectal cancerhMSH-2. Cf Familial adenomatous polyposis.


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35 PATHOLOGY OF MSI-H CANCER Identification of MSI-H cancer is potentially important for 3 reasons: MSI status may serve as a prognostic marker of survival, as a predictive marker of response to 5-fluorouracil- based chemotherapy,36 and as a screening tool for Lynch syndrome (a subset of hereditary nonpolyposis colon cancer, accounting for approximately 2% of all colorectal carcinomas).
Hereditary nonpolyposis colon cancer (HNPCC) syndrome is a genetic condition characterized by early-onset colorectal cancer (i.
Fishel R, Lescoe MK, Rao MR, et al: The human mutator gene homolog MSH2 and its association with hereditary nonpolyposis colon cancer.
 
 
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