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hereditary cancer syndrome

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hereditary cancer syndrome
Any of a group of often AD conditions characterized by tumors that are often site-specific, of early onset and multiple and/or bilateral; HCSs include nevoid basal cell carcinoma syndrome, dysplastic nevus–B-K mole syndrome, Cowden syndrome, familial polyposis, Gardner syndrome, Gorlin syndrome, Li-Fraumeni syndrome, MEN I, MEN II. See Beckwith Wiedemann syndrome, Cancer family, Dysplastic nevus sydrome, Familial malignancy, Hereditary neoplasmia, Hereditary preneoplasia, Li-Fraumeni syndrome.


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ELST is strongly associated with VHL disease, a hereditary cancer syndrome.
The critical first step in the identification of a hereditary cancer syndrome is to obtain a careful family history of cancer.
[23] Most hereditary cancer syndromes are associated with inactivation of tumor suppressor genes.
 
 
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