hepatoxicity

hepatoxicity

the quality of a substance which makes it toxic to liver cells.
References in periodicals archive ?
Hepatoxicity is the most frequent reason why drugs are pulled from the market, but its discovery could be expedited in some cases with reliable and systematic premarketing assessment (McPherson & Hemminki, 2004; Temple & Himmel, 2002).
Ongoing tests of sputum and blood draws are required to determine drug resistant strains of TB and hepatoxicity (Kandula et al.
Although, major and most common side effects of pyrazinamide are hepatoxicity and hyperuricaemia, its other side effects include arthralgia-itching, skin rash, gastrointestinal- anorexia, nausea, and abdominal pain.
details from health study findings on teratogenicity, developmental toxicity, carcinogenicity, immunotoxicity, renal toxicity, hepatoxicity, pulmonary toxicity, and neurotoxicity;
of Pennsylvania) provide a reference for diagnosing and treating acute and chronic liver diseases, including how to assess patients, viral and autoimmune hepatitis, nonviral infections, drug hepatoxicity, and cirrhosis.
Methylated thiopurine metabolites have been reported to be itninunosuppressive (25), and high concentrations of 6-MeMP have been implicated in hepatoxicity (26).
In-silico techniques- complex and accurate models for rationalising and predicting ADME properties- are allowing enhanced prediction of complex systems (for hepatoxicity and cardiotoxicity).
Apart from the concerns of hepatoxicity, rosiglitazone and pioglitazone are very well tolerated.
The Medical Letter indicates that usual doses of acetaminophen are not likely to cause hepatoxicity even in people who drink moderate amounts of alcohol.
3] VPA can cause rare, idiosyncratic hepatoxicity which is usually unaccompanied by fever, rash or other evidence of hypersensitivity.
Herbal medicine hepatoxicity is clearly underestimated for many reasons," he suggested.