For a study published in the Journal of Pharmacopuncture, researchers were investigating the aging process in mice, examining the roles of oxidative stress, cell death, hepatoxicity
, and neurotoxicity.
Curcumin Prevents Aflatoxin B1 Hepatoxicity
by Inhibition of Cytochrome P450 Isozymes in Chick Liver.
An overproduction of NAPQI which causes depletion of glutathione by reaction with glutathione to form 3-glutathion-S-yl-acetaminophen is a major problem worldwide and is produced by an overdose of APAP resulting in hepatoxicity
(Dahlin and Nelson, 1982; Hinson et al.
Antioxidant properties of Taraxacumofficinale leaf extract are involved in the protective effect against hepatoxicity
induced by acetaminophen in mice.
2008) The current state of serum biomarkers of hepatoxicity
Further research into new drugs is stymied by hepatoxicity
, which is "the main reason why many drugs are pulled from development.
The association between higher ALT and successful reintroduction of a standard treatment regimen is unexpected; it may represent true hepatoxicity
to PZA, which is reversible with drug cessation, or it may represent transient elevations of liver enzymes or unrelated liver injury as opposed to true TB DILI.
EFV can be used as a substitute to NVP if there is contraindication like hepatoxicity
, and EFV has got fetal teratogenicity in the first trimester of pregnancy.
Among mood stabilizers, carbamazepine and valproic acid are associated with the highest incidence of hepatoxicity
2), a molecular feature that is associated with high hepatoxicity
Interactions among these medications may result in cytotoxicity and hepatoxicity
and/or amplify depression and alter the metabolism of certain drugs.
Hepatoprotective activity of Vitex negundo leaf extract against anti-tubercular drugs induced hepatoxicity