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hepatic metabolism

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hepatic metabolism
Therapeutics The constellation of chemical alterations to drugs or metabolites that occur in the liver, carried out by microsomal enzyme systems, which catalyze glucuronide conjugation, drug oxidation, reduction and hydrolysis. See Metabolism.


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Recommendations Rifampicin potently induces the hepatic metabolism of COCs, and extra contraceptive methods should be employed.
Inappropriate or no adjustment of a QT prolonging agent's dosing in patients with reduced creatinine clearance or reduced hepatic metabolism was defined according to the pharmacokinetics of the offending agent.
Because CRP is synthesized in the liver, we hypothesized that estrogeninduced CRP elevation is related to first-pass hepatic metabolism.
 
 
 
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