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hepatic metabolism |
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hepatic metabolism Therapeutics The constellation of chemical alterations to drugs or metabolites that occur in the liver, carried out by microsomal enzyme systems, which catalyze glucuronide conjugation, drug oxidation, reduction and
hydrolysis. See Metabolism. How to thank TFD for its existence? Tell a friend about us, add a link to this page, add the site to iGoogle, or visit webmaster's page for free fun content. |
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Inappropriate or no adjustment of a QT prolonging agent's dosing in patients with reduced creatinine clearance or reduced hepatic metabolism was defined according to the pharmacokinetics of the offending agent. Regardless of the mechanism in which this drug interaction had occurred (alterations of hepatic metabolism via cytochrome enzymes, gastric acid suppression or p-glycoprotein inhibition), this case reminds clinicians of the need to remain vigilant with respect to every conceivable factor in relation to their patient when presented with medication toxicity or changes in their patient's condition. The IP agent should have rapid and extensive hepatic metabolism into nontoxic metabolites during the first pass through the liver. |
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