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hepatic insufficiency

   Also found in: Dictionary/thesaurus, Legal 0.15 sec.
hepatic insufficiency,
a failure or partial failure of normal liver function.

insufficiency
inability to perform properly an allotted function.

adrenal insufficiency
hypoadrenalism.
aortic insufficiency
inadequacy of the aortic valve, permitting blood to flow back into the left ventricle of the heart.
cardiac insufficiency
inability of the heart to perform its function properly; heart failure.
coronary insufficiency
decreased supply of blood to the myocardium resulting from constriction or obstruction of the coronary arteries, but not accompanied by necrosis of the myocardial cells. Called also ischemic myocardial necrosis.
hepatic insufficiency
inadequate liver function, short of hepatic failure.
ileocecal insufficiency
inability of the ileocecal valve to prevent backflow of contents from the cecum into the ileum.
pulmonary insufficiency
insufficiency of the pulmonary valve, permitting blood to flow into the right ventricle of the heart.
respiratory insufficiency
a condition in which respiratory function is inadequate to meet the body's needs when increased physical activity places extra demands on it. See also respiratory insufficiency.
thyroid insufficiency
hypothyroidism.
valvular insufficiency
failure of a cardiac valve to close perfectly, causing the blood to flow back through the orifice (valvular regurgitation); named, according to the valve affected, aortic, mitral, pulmonary or tricuspid insufficiency.
velopharyngeal insufficiency
failure of velopharyngeal closure due to cleft palate, muscular dysfunction, etc., resulting in defective swallowing with regurgitation through the nose.
venous insufficiency
inadequacy of the venous valves with impairment of venous drainage, resulting in edema.


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? Mentioned in ? References in periodicals archive
 
No dosage adjustment is needed for patients with mild to moderate hepatic insufficiency or in patients with mild renal insufficiency (CrCl [greater than or equal to]50 mL/min).
Hepatic Insufficiency Plasma concentrations of caspofungin after a single 70-mg dose in patients with mild hepatic insufficiency (Child-Pugh score 5 to 6) were increased by approximately 55% in AUC compared to healthy control subjects.
No dosage adjustment is needed for patients with mild to moderate hepatic insufficiency or in patients with mild renal insufficiency (CrCl [greater than or equal to]50 mL/min).
 
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