hepatic clearance

hepatic clearance

Therapeutics The hypothetical calculation of the volume of distribution in liters of unmetabolized drug cleared through the liver in 1 min–L/min. See Clearance.
References in periodicals archive ?
Title: CPX-351 Markedly Reduces Renal and Hepatic Clearance Rates for Cytarabine (Cyt) and Daunorubicin (Daun) in Rats with an Associated Decrease in Excretory and Metabolic Burden Despite Providing Dramatic Increases in Systemic Drug Exposure Compared to Conventional Cyt+Daun Abstract # 2305 Session: Acute Myeloid Leukemia: Novel Therapy, excluding Transplantation: Poster II
The findings should allay fears that decreased hepatic clearance of statins could lead to complications in patients with advanced liver disease, said lead investigator Dr.
Hepatic clearance of tissue-type plasminogen activator and plasma kallikrein in experimental liver fibrosis.
Introducing concepts in ways that do not require an intensive mathematical background, he covers the pharmacokinetic behavior of drugs administered intravenously, orally and by intravenous infusion, addressing principles and then the specifics of single intravenous administration, drug absorption following oral administration (including biopharmaceutical considerations and rates), steady states during multiple drug administrations, renal drug elimination, metabolic pharmacokinetics, disease state and drug pharmacokinetics, nonlinear pharmacokinetics, multi-component pharmacokinetic models, intermittent intravenous infusion, data analysis, physiological approaches to hepatic clearance, and the relationship between pharmacokinetics and pharmacodynamics and therapeutic drug monitoring.
Although liver-associated enzymes were not measured at admission, there were no signs, symptoms, clinical or physical examination evidence of an acute hepatitis that might have altered hepatic clearance of digoxin.
This is consistent with other evidence (Schmucker 2001) and suggests that multiple factors such as less blood flow to the liver, smaller liver mass, and decreased specific content of CYPs may combine in elderly individuals to decrease hepatic clearance of drugs.
Spitz finds disconcerting because of the drug's narrow therapeutic range, complex pharmacokinetics, associated accelerated bone loss, and reduced hepatic clearance in the elderly.
Keep in mind the altered pharmacokinetics and pharmacodynamics among the elderly when prescribing medications, lower the target dosing, and adjust for liver and hepatic clearance, he advised.
Image with caption: "Hepatic Clearance: Summary table showing clearance data for a selection of compounds in a hepatic clearance study in Accelrys Morphit.
Because apolipoproteins are ligands for hepatic lipoprotein receptors, transfer of apolipoproteins to the injected RLPs from endogenous lipoproteins in the circulation is a critical requirement for hepatic clearance of the emulsion.
Biodistribution data and inhibition of hepatic uptake by asialofetuin indicated that the hepatic clearance of Sm-arabinogalactan was mediated by the ASGP-R.