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hepatic clearance |
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hepatic clearance Therapeutics The hypothetical calculation of the volume of distribution in liters of unmetabolized drug cleared through the liver in 1 min–L/min. See Clearance. How to thank TFD for its existence? Tell a friend about us, add a link to this page, add the site to iGoogle, or visit webmaster's page for free fun content. |
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Although liver-associated enzymes were not measured at admission, there were no signs, symptoms, clinical or physical examination evidence of an acute hepatitis that might have altered hepatic clearance of digoxin. 30 Because omeprazole is an intermediate hepatic extraction ratio drug (hepatic first-pass effect of approximately 60%30) in rats, the hepatic clearance of omeprazole in rats depends on the hepatic blood flow rate, free (unbound to plasma proteins) fractions of omeprazole in plasma, and CL^sub int^. 2004) also assume a constant hepatic clearance rate for TCDD. |
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