heparin-induced thrombocytopenia


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Related to heparin-induced thrombocytopenia: thrombin, disseminated intravascular coagulation

heparin-induced thrombocytopenia

Acquired thrombocytopenia affecting some heparin-treated Pts–HTPs, defined as a ↓ platelet count during or shortly after heparin exposure; HIT is a markedly prothrombotic disorder seen in Pts who are at a high baseline risk for venous thrombosis DiffDx Antiphospholipid antibody syndrome, DIC, Trousseau syndrome–migratory thrombophlebitis & malignancy, TTP/HUS, thrombocytopenia and 'showers' of microthrombi Clinical HIT occurs 6-10 days after heparin exposure Diagnosis Aggregation studies using platelets from Pts known to be sensitive to antibody; quantification of serotonin release from platelets radiolabeled with serotonin in assay using Pt serum.

heparin-induced thrombocytopenia

Thrombocytopenia caused by an immune reaction to heparin. It may lead to widespread or potentially life-threatening blood clotting rather than bleeding. See: white-clot syndrome

CAUTION!

Patients whose platelet counts drop significantly during exposure to heparin should discontinue the drug immediately.

heparin-induced thrombocytopenia

A blood platelet deficiency disorder caused by a reaction to heparin. The condition is caused by antibodies, usually of the IgG class against a heparin-platelet factor IV complex on the surface of platelets. Paradoxically, the condition features thrombosis and embolism with the risk of stroke and other serious arterial occlusion effects. This is because the immune complexes formed combine with the antibody Fc receptors of platelets causing their activation and the initiation of clotting.
References in periodicals archive ?
Lepirudin in heparin-induced thrombocytopenia and extracorporeal membranous oxygenation.
A 14-year study of heparin-induced thrombocytopenia.
Reducing thrombotic complications in the peri-operative setting: An update on heparin-induced thrombocytopenia.
Plasma-modified ACT can be used to monitor bivalirudin (Angiomax) anticoagulation for on-pump cardiopulmonary bypass surgery in a patient with heparin-induced thrombocytopenia.
The pathophysiology of heparin-induced thrombocytopenia.
Argatroban and renal replacement therapy in patients with heparin-induced thrombocytopenia.
We present the case of a patient being treated with heparin for a deep-vein thrombosis, who subsequently developed heparin-induced thrombocytopenia and lingual hematoma, necessitating tracheotomy.
Clinicians identified an opportunity to cut costs by using nonheparinized solutions for maintaining patency of these catheters; in addition, there is a real concern regarding the risk for the development of heparin-induced thrombocytopenia (HIT).
His subsequent course was complicated by heparin-induced thrombocytopenia.
1) The use of low-molecular-weight heparin (LMWH) is preferred to unfractionated heparin (UFH) as it is associated with a lower risk of bleeding, osteoporosis, heparin-induced thrombocytopenia (HIT) and hypersensitivity reactions.

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