heparin-binding protein


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AZU1

A gene on chromosome 19q13.3 that encodes an azurophil granule protein of the serine protease family (but is not itself a serine protease), which has monocyte chemotactic and antibacterial activity, and acts as an important multifunctional inflammatory mediator. The genes encoding the AZU1 protein product, neutrophil elastase 2 and proteinase 3, are in a cluster at chromosome 19pter, and all three are expressed and packaged together into azurophil granules during neutrophil differentiation.

heparin-binding protein

A proinflammatory, antimicrobial peptide released by neutrophils. It increases the permeability of blood vessels. It is found in high concentrations in plasma of patients with septic shock.
See also: protein
References in periodicals archive ?
Perhaps the most significant discovery has been the participation of heparin-binding proteins (HBPs) in the sperm capacitation (THERIEN et al.
Heparin-binding proteins from seminal plasma bind to bovine spermatozoa and modulate capacitation by heparin.
d] of -16 pmol/L, a photo cross-linking yield of 50%, and specific binding to bFGF that is more than three orders of magnitude higher than binding to other heparin-binding proteins, such as vascular endothelial growth factor and platelet-derived growth factor (13).

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