heparin /hep·a·rin/ (hep´ah-rin) a sulfated glycosaminoglycan of mixed composition, released by mast cells and by blood basophils in many tissues, especially the liver and lungs, and having potent anticoagulant properties. It also has lipotrophic properties, promoting transfer of fat from blood to the fat depots by activation of lipoprotein lipase. It is used as the calcium or sodium salt in the prophylaxis and treatment of disorders in which there is excessive or undesirable clotting and to prevent clotting during extracorporeal circulation, blood transfusion, and blood sampling.
Heparin
heparin
heparin
hep·a·rin (h p  r- n)n. A complex organic acid that is found especially in lung and liver tissue, has a mucopolysaccharide as its active constituent, prevents platelet agglutination and blood clotting, and is used in the form of its sodium salt in the treatment of thrombosis. hep  a·rini·zation (--rn-z shn) n.hep a·rin·ize (-r--n z) v. |
Heparin
An organic acid that occurs naturally in the body and prevents blood clots. Heparin is also made synthetically and can be given as a treatment when required.
Mentioned in: Coagulation Disorders, Hypercoagulation Disorders, Partial Thromboplastin Time, Puerperal Infection, Thyroid Function Tests
heparin
[hep′ərin]
Etymology: Gk, hēpar, liver
a naturally occurring mucopolysaccharide that acts in the body as an antithrombin factor to prevent intravascular clotting. The substance is produced by basophils and mast cells, which are found in large numbers in the connective tissue surrounding capillaries, particularly in the lungs and liver. In the form of sodium salt, heparin is used therapeutically as an anticoagulant. See also heparin sodium.
heparin
an acid mucopolysaccharide present in many tissues, especially the liver and lungs, and having potent anticoagulant properties. It also has lipotrophic properties, promoting transfer of fat from blood to the fat depots by activation of lipoprotein lipase. Also, a mixture of active principles capable of prolonging blood clotting time, obtained from domestic animals; used in the prophylaxis and treatment of disorders in which there is excessive or undesirable clotting and as a preservative for blood specimens.
heparin
Hematology A sulfated glycosaminoglycan anticoagulant that inhibits activated factors IXa, Xa, XIa, XIIa and thrombin, ↓ local anti-thrombin-III, promoting its inactivation by neutrophil elastase; interaction of heparin with
endothelial cells results in displacement of platelet factor 4, which inactivates heparin Indications Thromboembolism, CAD, post acute MI, PTE Monitoring Titrate heparin so that aPTT is 1.5-2.0-fold normal Side effects Hemorrhage, thrombocytopenia,
osteoporosis, skin necrosis, alopecia, hypersensitivity, hypoaldosteronism. See Low-molecular weight heparin.
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