20 Over-expression of miR-558 in NB cell lines promoted invasion, metastasis and angiogenesis in vitro and in vivo via heparanase
(HPSE); in contrast, knockdown of endogenous miR-558 had the opposite effect.
166) - Pipeline Review, H1 2016', provides in depth analysis on Heparanase
(Endo-Glucoronidase or Heparanase
-1 or EC 3.
Domann, "Overexpression of extracellular superoxide dismutase attenuates heparanase
expression and inhibits breast carcinoma cell growth and invasion," Cancer Research, vol.
Increased expression of heparanase
in overt diabetic nephropathy.
100,115,117,118) Other proteases that have been shown to contribute to HNSCC invasion include MMP-10, (66) MMP-13, (80) matriptase, (119) fibroblast activation protein, (120) and uPA/ uPAR, (117,121-124) as well as the glycosidase heparanase
localization during palatogenesis in mice.
Cell wall metabolism Heparanase
precursor Cell wall-associated hydrolase Cell wall-associated hydrolase Cell wall-associated hydrolase Cell wall-associated hydrolase Cell wall-associated hydrolase Cell wall-associated hydrolase Cell wall-associated hydrolase Glycoside hydrolases Glycosyl transferase family protein 30S ribosomal protein S13 11.
PG545, a dual heparanase
and angiogenesis inhibitor, induces potent anti-tumour and anti-metastatic efficacy in preclinical models.
Platelet components, such as vascular endothelial growth factor (VEGF), platelet-derived growth factor, basic fibroblast growth factor (bFGF), and heparanase
, have all been shown to be involved in mediating these endothelial functions (49).
Endothelial cell injury by high glucose and heparanase
is prevented by insulin, heparin and basic fibroblast growth factor.
Qin Q, Niu J, Wang Z, Xu W, Qiao Z, Cu Y Astragalus membranaceus extract activates immune response in macrophages via heparanase
PI-88 is a multi-targeted cancer therapeutic in late stage development which inhibits both angiogenesis (or tumour promoting) factors such as Vascular Endothelial Growth Factor (VEGF), Fibroblast Growth Factors (FGF) 1 and 2, and heparanase
, an enzyme implicated in metastasis.