heparan sulfate


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Related to heparan sulfate: keratan sulfate, dermatan sulfate

heparan sulfate

 [hep´ah-ran]
a sulfated mucopolysaccharide structurally related to heparin, which occurs normally in the liver, aorta, and lung; it is an accumulation product in several mucopolysaccharidoses.

hep·a·ran sul·fate

(hep'ă-ran sŭl'fāt),
A heteropolysaccharide that has the same repeating disaccharide as heparin but with fewer sulfates and more acetyl groups; accumulates in people with certain types of mucopolysaccharidosis.
Synonym(s): heparitin sulfate

heparan sulfate

/hep·a·ran sul·fate/ (hep´ah-ran) a glycosaminoglycan occurring in the cell membrane of most cells, consisting of a repeating disaccharide unit of glucosamine and uronic acid residues, which may be acetylated and sulfated; it accumulates in several mucopolysaccharidoses.

heparan sulfate

(hĕp′ə-răn)
n.
A glycosaminoglycan found on cell surfaces and basement membranes in mammals that regulates a wide variety of biological processes, including angiogenesis and blood coagulation. Also called heparitin sulfate.

heparan sulfate

a sulfated mucopolysaccharide structurally related to heparin, which occurs normally in the liver, aorta and lung; it is an accumulation product in several mucopolysaccharidoses.
References in periodicals archive ?
Presence of heparan sulfate in the glomerular basement membrane.
To provide this service, heparanase cleaves a carbohydrate called heparan sulfate, one of the components of tough organic sheets located throughout the body.
Developmental changes in heparan sulfate expression: in situ detection with mAbs.
Heparan sulfate glycosaminoglycans as primary cell surface receptors for herpes simplex virus.
Olgemoller B, Schleicher ED, Schwaabe S, Guretzki H-J, Gerbitz KD (1990) High concentrations of low density lipoprotein decrease basement membrane-associated heparan sulfate proteoglycan in cultured endothelial cells.
The researchers obtained similar results when they injected mice with the heparan sulfate fragments themselves, rather than the enzymes.
Snow (now ProteoTech President & CSO), Ken-ichiro Fukuchi, and John Hassell, relate to the generation of novel genetically engineered mice that overproduce a particular heparan sulfate proteoglycan that has been implicated to play an important role in a variety of human diseases, including Alzheimer's and other amyloid disorders.
This macromolecule naturally co-exists with several other known GAGs, including keratan sulfate, heparin, heparan sulfate and dermatan sulfate.
The system is intended to replicate the body's measured delivery of growth factors by heparan sulfate reservoirs, Rabolt says.
Developmental and cell-type-specific expression of cell surface heparan sulfate proteoglycans in the rat heart.