and HUS attributable to STEC were recognized after trimethoprim and the 4-quinolones were introduced into human and veterinary clinical practice, and the substantial recent increase in reports of STEC disease follows expanded use of fluoroquinolones.
Shiga toxins 1 and 2 are the main virulence factors associated with hemorrhagic colitis
and HUS, presumably because they interact with endothelial cells at the site of infection and in the glomeruli and arterioles of the kidney (17).
3 Patient is hospitalized for hemorrhagic colitis
More cases with strains producing VT1+2 had hemorrhagic colitis
Swimming-associated hemorrhagic colitis
due to Escherichia coli O157:H7 infection: evidence of prolonged contamination of a fresh water lake.
Infection often leads to abdominal cramps, hemorrhagic colitis
, and in some cases -- particularly children and the elderly -- the infection can also cause hemolytic uremic syndrome, in which red blood cells are destroyed and the kidneys fail.
To the Editor: Infection by Shiga toxin (Stx)-producing Escherichia coli (STEC), particularly strains of serotype O157:H7, can cause sporadic cases and outbreaks of diarrhea, hemorrhagic colitis
(HC), and hemolytic uremic syndrome (HUS) (1).
coli (STEC), including the O157:H7 strain involved in the current US outbreak, cause severe clinical symptoms such as hemorrhagic colitis
, thrombocytopenia, hemolytic anemia and hemolytic uremic syndrome in up to 60% of all infected patients, and are potentially lethal in the most severe cases.
Enterohemorrhagic Escherichia coli (EHEC) O157:H7 is the serotype most commonly associated with hemorrhagic colitis
and the hemolytic uremic syndrome (1).
coli (EHEC), has been linked to numerous foodborne outbreaks and sporadic cases of hemorrhagic colitis
and hemolytic uremic syndrome worldwide.
Infection of VTEC in humans has been associated with various diseases including hemorrhagic colitis
, hemolytic-uremic syndrome and even death.
coli O157:H7 has been a major cause of hemorrhagic colitis
and hemolytic uremic syndrome in North America.