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hemolytic transfusion reaction

   Also found in: Acronyms 0.03 sec.
hemolytic transfusion reaction
Transfusion medicine A therapy-related event mediated by 2 different mechanisms: 1. Intravascular hemolysis mediated by complement-fixing antibodies, 2. Extravascular hemolysis mediated by noncomplement-fixing antibodies Clinical Fever, chills, pain at infusion site, intense back pain, hypotension, sense of impending doom, chest tightness, acute dyspnea, brochospasm, anaphylaxis, hyperbilirubinemia, hemoglobinuria, DIC with fibrinolysis Management Stop transfusion, treat shock–vasopressors, IV fluids, cortiocosteroids, maintain high fluid throughput, monitor anemia, transfuse with compatible blood


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Our differential diagnosis was a delayed hemolytic transfusion reaction versus autoimmune hemolytic anemia.
Daniels (Bristol Institute for Transfusion Services) and Bromilow (DiaMed AG) describe the ABO, Rh, Kell, Duffy, Kidd, MNS, Diego, and Lewis blood group systems, and explain the clinical significance of blood group antibodies causing hemolytic transfusion reaction and hemolytic disease of the fetus and newborn.
HTR - Hemolytic Transfusion Reaction (blood transfusion)
 
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