hemoglobin C disease

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Related to hemoglobin C disease: hemoglobin SC disease

he·mo·glo·bin C dis·ease

the homozygous state of hemoglobin C.

hemoglobin C disease

an inherited hemoglobinopathy caused by hemoglobin C. The heterozygous form is asymptomatic; homozygous hemoglobin C disease causes a mild to moderate hemolytic anemia. In the homozygous form, target cells and hemoglobin C crystals are seen in microscopic examination of a blood film. See also hemoglobin C, hemoglobin SC disease.

hemoglobin C disease

Hematology An AR hemoglobinopathy most commonly affecting blacks, characterized by intermittent abdominal pain, arthralgias, headaches, splenomegaly, cholecystitis, gallstones Lab Mild–33% Hct anemia, 2–6% reticulocyte count; 90% of RBCs are targetoid, often with HbC crystals; ↑ iron turnover, ↓ RBC survival. Cf Sickle cell anemia.

Hemoglobin C disease

A disease of abnormal hemoglobin, occurring in 2-3% of African-Americans. Only those who have two genes for the disease develop anemia, which varies in severity. Symptoms include episodes of abdominal and joint pain, an enlarged spleen and mild jaundice.