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hemoglobin Bart's

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hemoglobin Bart's,
an abnormal hemoglobin composed of four gamma chains having high oxygen affinity, seen in Southeast Asians and a few other groups. Infants born with only this type of hemoglobin have hydrops fetalis and usually die within a few hours. Hemoglobin Bart's is often found mixed with hemoglobin H, resulting in alpha-thalassemia.


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Deletion of three alpha globin genes results in Hemoglobin H disease, with 4-30% rapidly migrating hemoglobin H and a small amount of hemoglobin Bart's.
PAT-3. Hemoglobin H disease mimics a normal pattern on hemoglobin ... by Posey, Y.F. / Southern Medical Journal
 
 
 
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