hemidesmosome


Also found in: Dictionary, Encyclopedia, Wikipedia.
Related to hemidesmosome: Adherens junction, Gap junctions

hemidesmosome

/hemi·des·mo·some/ (-des´mo-sōm) a structure representing half of a desmosome, found on the basal surface of some epithelial cells, forming the site of attachment between the basal surface of the cell and the basement membrane.

desmosome

A site of adhesion between two adjacent cells, such as in the corneal epithelium. It consists of a small, dense body in which the two halves are separated by an intercellular gap filled with extracellular substance. The basal cells are attached at irregular intervals to the underlying basement membrane (adjacent to Bowman's layer) by hemidesmosomes (one half of a desmosome). Thus, scraping off the epithelium usually leaves fragments of the basal cells attached to the basement membrane.

hemidesmosome

see half desmosome.
References in periodicals archive ?
The cytoplasmic extensions formed connections with each other, and with connective tissue in the form of hemidesmosomes.
We speculate that there could be cooperation between IFAP300 and BP230, in that there may be multiple proteins linking intermediate filaments at the cell surface in intact, complete hemidesmosomes.
Our results indicate that the G domain of laminin-5 appears to be essential for both epithelial cell interaction and nucleation of hemidesmosome assembly.
Integrin alpha 6/beta 4 complex is located in hemidesmosomes, suggesting a major role in epidermal cell-basement membrane adhesion," Journal of Cell Biology, vol.
Unlike adherens junctions, hemidesmosomes affix the basal plasma membrane to the tissue's basal membrane (cell-extracellular matrix junction) via integrins a6P4 and laminin 5 filaments.
It is believed that the pathophisiology of laminitis is related to high degradation of the basement membrane (BM), caused by metalloproteases (MMPs), and/or loss of hemidesmosomes present in the secondary epidermal laminae.
The functional integrity of horn depends on effective epidermal adhesion and this involves proteins such as cadherins and hemidesmosomes which connect cells to the basement membrane with anchorage by proteins such as integrins.
26) Instead, the junctional epithelium is present in these areas and consists of hemidesmosomes and basal lamina.
The thin basal processes of these cells span the height of the epithelium and are linked to the basal lamina by hemidesmosomes.
Papers cover elementary integrin signaling, integrin signaling through focal adhesion kinase, the Paxillin family and tissue remodeling, adhesion dynamics in motile cells, integrin trafficking, hemidesmosomes and their components (adhesion v.
Viable cells break away from their support in a complex process involving signal transduction mechanisms (from inside to outside the cell) that result in conformational changes of the extracellular domain of desmosomes and hemidesmosomes [8].