hematogone

hematogone

a lymphocyte-like cell appearing in the bone marrow as a nucleus without a cell cytoplasm. Considered to be a blood cell precursor.
References in periodicals archive ?
Stage 2 hematogones represent the majority of the hematogone population.
In the presented case stage 2 hematogones comprised the majority of the hematogone population, as was reported in most other cases (7).
In conclusion, excessive hematogones in the bone marrow of children may cause problems in diagnostically differentiating acute lymphoblastic leukemia from a benign hematogone proliferative state, and flow cytometric analysis may help differentiate these 2 cell populations.
In all instances the hematogone population exhibited a typical complex spectrum of antigens of B-lineage precursors.
Bone marrow hematogones were separately assessed as hematogone 1 populations of early stage and hematogones 2 of mid-stage precursor B cells, respectively.
Hematogone populations always exhibit a continuous and complete maturation spectrum of antigen expression typical of the normal evolution of B-lineage precursors and they lack aberrant or asynchronous antigen expression (5).
Identification of immunophenotypic aberrancies can be essential to differentiate a small bilineal blast population from residual normal myeloid blasts or hematogones (physiological B-cell precursors).
Immunophenotypic analysis of hematogones (B-lymphocyte precursors) in 662 consecutive bone marrow specimens by 4-color flow cytometry.
In particular, normal hematogones are initially [CD10.
In fact, hematogones are frequently increased in regenerating, posttherapy bone marrow, but they do retain their characteristic immunophenotypic features.
Using molecular studies, hematogones have their IgH and T-cell receptor genes in a germline configuration, thus supporting the benign nature of this unique bone marrow population.
Although the extent of hematogones has been elucidated in several pathologic settings, to our knowledge no reports on increased hematogones in SDS have been published to date.