hemagglutination

hemagglutination /he·mag·glu·ti·na·tion/ (he″mah-gloo-tĭ-na´shun) agglutination of erythrocytes.

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he·mag·glu·ti·na·tion (hm-gltn-shn)

n.

The agglutination of red blood cells caused by an antibody either for red blood cell antigens or for antigens that coat red blood cells or by the presence of viruses or other microbes.

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hemag·gluti·nate v.

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Hemagglutination

The clumping or clustering of red blood cells caused by certain viruses, antibodies, or other substances.

Mentioned in: Rubella Test

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hemagglutination

[hē′məglo̅o̅′tinā′shən, hem′-]

Etymology: Gk, haima + L, agglutinare, to glue

the coagulation of erythrocytes. See also blood clotting.

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hemagglutination [he″mah-gloo″tĭ-na´shun]

agglutination of erythrocytes.

hemagglutination inhibition (HI, HAI) test

1. a highly sensitive procedure for the measurement of soluble antigens in biologic specimens; the amount of hemagglutination reflects the amount of free antibody present after reaction with the specimen and thus varies inversely with amount of antigen in the specimen.

2. a procedure for the measurement of serum antibodies directed against a hemagglutinating virus; the highest dilution of serum that completely inhibits hemagglutination by a standardized viral preparation is reported as the hemagglutination titer.

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hemagglutination

agglutination of erythrocytes usually by either antibodies, viruses or certain plant lectins; abbreviated HA.

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indirect hemagglutination test

see hemagglutination inhibition test (below).

hemagglutination inhibition (HI) test

an assay for the presence of specific antiviral antibodies in a test serum. The serum, usually a twofold dilution series, is mixed with a standard number, usually 4 to 8 HA units, of virus and incubated prior to the addition of a standard suspension of erythrocytes. The highest dilution of serum that inhibits hemagglutination is the HI titer of the serum.

passive hemagglutination test

see passive agglutination test.

hemagglutination (HA) test

hemagglutinating viruses directly agglutinate erythrocytes by binding to specific receptor sites on the surface of the erythrocyte and this characteristic can be used in detection, identification and quantitation of the virus.

hemagglutination viruses

viruses capable of agglutinating red blood cells of a variety of animals, e.g. adenoviruses, parvoviruses, togaviruses, some coronaviruses, picornaviruses, orthomyxoviruses and paramyxoviruses. Useful in classifying viruses and assaying amounts of virus and antibody. See also hemadsorption.