Held


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Held

(held),
Hans, German anatomist, 1866-1942. See: Held bundle, Held decussation.

ARID1A

A gene on chromosome 1p36.1-p35 that encodes AT-rich interactive domain-containing protein 1, which is highly expressed in the spleen, thymus, prostate, testes, ovaries, small intestine, colon and peripheral leukocytes. ARID1A is involved in transcriptional activation and repression of select genes by chromatin remodelling (by altering DNA-nucleosome topology). It is also involved in vitamin D-coupled transcription regulation by associating with the WINAC complex, a chromatin-remodelling complex recruited by vitamin D receptor.

ARID1A belongs to the neural progenitors-specific chromatin remodelling (npBAF) and the neuron-specific chromatin remodelling (nBAF) complexes, which are involved in switching developing neurons from stem/progenitors to post-mitotic chromatin remodelling as they exit the cell cycle and become committed to their adult state.

Molecular pathology
Defects in ARID1A cause mental retardation autosomal dominant type 14.
References in classic literature ?
Those again who held Pelasgic Argos, Alos, Alope, and Trachis; and those of Phthia and Hellas the land of fair women, who were called Myrmidons, Hellenes, and Achaeans; these had fifty ships, over which Achilles was in command.
And those that held Phylace and the flowery meadows of Pyrasus, sanctuary of Ceres; Iton, the mother of sheep; Antrum upon the sea, and Pteleum that lies upon the grass lands.
And those that held Pherae by the Boebean lake, with Boebe, Glaphyrae, and the populous city of Iolcus, these with their eleven ships were led by Eumelus, son of Admetus, whom Alcestis bore to him, loveliest of the daughters of Pelias.
And those that held Methone and Thaumacia, with Meliboea and rugged Olizon, these were led by the skilful archer Philoctetes, and they had seven ships, each with fifty oarsmen all of them good archers; but Philoctetes was lying in great pain in the Island of Lemnos, where the sons of the Achaeans left him, for he had been bitten by a poisonous water snake.
Those, again, of Tricca and the stony region of Ithome, and they that held Oechalia, the city of Oechalian Eurytus, these were commanded by the two sons of Aesculapius, skilled in the art of healing, Podalirius and Machaon.
The men, moreover, of Ormenius, and by the fountain of Hypereia, with those that held Asterius, and the white crests of Titanus, these were led by Eurypylus, the son of Euaemon, and with them there came forty ships.
Those that held Argissa and Gyrtone, Orthe, Elone, and the white city of Oloosson, of these brave Polypoetes was leader.
Guneus brought two and twenty ships from Cyphus, and he was followed by the Enienes and the valiant Peraebi, who dwelt about wintry Dodona, and held the lands round the lovely river Titaresius, which sends its waters into the Peneus.
They that held Adresteia and the land of Apaesus, with Pityeia, and the high mountain of Tereia--these were led by Adrestus and Amphius, whose breastplate was of linen.
These were they that held Cytorus and the country round Sesamus, with the cities by the river Parthenius, Cromna, Aegialus, and lofty Erithini.
These held Miletus and the wooded mountain of Phthires, with the water of the river Maeander and the lofty crests of Mt.
At the castle which is held by the brave knight, Sir Nigel Loring, constable to the Earl of Salisbury.