heavy chains


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heavy chains

The large polypeptide chains of antibodies.
See: heavy chain disease
See also: chain

heavy chains

Polypeptides forming the main part of the Y structure of an ANTIBODY, including the stalk and the inner edges of the two upper arms. Each heavy chain contains one variable region and three or four fixed domains. Attached to the outer side of the upper arm parts of the heavy chains are the two LIGHT CHAINS. The area between the free upper ends of the two pairs of chains is known as the N terminal. This is the antigen combining site and is the variable part of the antibody allowing for the enormous range of different specificities.
References in periodicals archive ?
Cardiomyopathy: a systematic review of disease-causing mutations in myosin heavy chain 7 and their phenotypic manifestations.
The outer arm dynein of metazoan sperm is comprised of two heavy chains (HC; [alpha], [beta], ~500 kDa, three to five intermediate chains (IC;60-120 kDa, and six light chains (LC; 8-30 kDa) (36,37) (Fig.
Human immunoglobulins are broadly classified into five major serologically different heavy chain isotypes (IgM, IgG, IgA, IgD and IgE) and two distinct light chain isotypes (Kappa and Lambda) (1).
Sunder was rocking gently - typical behaviour by such an animal under stress, all four legs shackled by heavy chains.
Annie - Britain's last circus elephant - was secretly filmed being struck with a metal pitchfork, kicked in the face and body 48 times and shackled by heavy chains at the Bobby Roberts Super Circus.
Annie the Asian elephant was filmed being struck with a metal pitchfork, kicked in the face and body and shackled by heavy chains at the Bobby Roberts Super Circus.
2-4) When the light chains are attached to the heavy chains, the light chains are referred to as bound light chains and when they are not attached to heavy chains they are called as free light chains.
All of that unleashes, and the tree and the dry dirt outside and the dusty wood floor and the wrists and the heavy chains and the way I, the child, the girl, lay on her belly, stretched out, her shirt and pants getting dusty, her belly on the coolness of the floor, wood slats, the smoothness, the body stretched out, the girl, listening, not listening, knowing what they do, she can't help but hear, feels it's her fault because she is there, because she is alive, because she can hear, because she cannot stop them.
However, on Christmas Eve Scrooge is visited by the ghost of his former business partner, Jacob Marley, who is now forced to spend his afterlife carrying heavy chains forged from his own greedy ways.
Most patients with CSH have a serum paraprotein composed of [kappa] light chain, but the heavy chains can be varied.