heavy chains


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heavy chains

The large polypeptide chains of antibodies.
See: heavy chain disease
See also: chain

heavy chains

Polypeptides forming the main part of the Y structure of an ANTIBODY, including the stalk and the inner edges of the two upper arms. Each heavy chain contains one variable region and three or four fixed domains. Attached to the outer side of the upper arm parts of the heavy chains are the two LIGHT CHAINS. The area between the free upper ends of the two pairs of chains is known as the N terminal. This is the antigen combining site and is the variable part of the antibody allowing for the enormous range of different specificities.
References in periodicals archive ?
a high degree of specificity, so they recognize immunoglobulin light chains when they are free but not when they are bound to heavy chains in intact immunoglobulin molecules; and
Look forward and we see the chance to shake off those heavy chains of history.
The recent technical improvements described, which have played an important part in recent advances, include the expression and preparation of recombinant dynein heavy chains or individual subdomains.
In one yard, 114 dogs, the majority tethered to heavy chains, sat in 90 degree heat, scratching at fleas, with no fresh water or food visible anywhere on the property.
Isotype characterization is generally straightforward, but IgD and IgE heavy chains may be missed because most laboratories do not routinely include IgD and IgE heavy chains in their IFE procedures.
Most patients with CSH have a serum paraprotein composed of [kappa] light chain, but the heavy chains can be varied.
I hope so anyway, otherwise the boys downstairs may as well start banging my heavy chains together.
Eamon Butterly had put heavy chains on the exits to stop people getting into the club for free.
The EP0656946 patent is based on the elucidation at VUB of the structure of a particular class of camelid antibodies that consist solely of heavy chains (as opposed to human antibodies which consist of heavy and light chains).
30am yesterday when he began climbing one of the heavy chains which hold up the bridge.
STYLE: Chavs are likely to be seen in Burberry caps, heavy chains and new trainers; HANG-OUT: Broadgate is said to be a Chavs' spot
People want heavy chains or bangles, or earrings including diamonds or stones - very much the bling bling.