heavy chains


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heavy chains

The large polypeptide chains of antibodies.
See: heavy chain disease
See also: chain

heavy chains

Polypeptides forming the main part of the Y structure of an ANTIBODY, including the stalk and the inner edges of the two upper arms. Each heavy chain contains one variable region and three or four fixed domains. Attached to the outer side of the upper arm parts of the heavy chains are the two LIGHT CHAINS. The area between the free upper ends of the two pairs of chains is known as the N terminal. This is the antigen combining site and is the variable part of the antibody allowing for the enormous range of different specificities.
References in periodicals archive ?
Using the mass spectra of isolated heavy chains is challenging due to variable glycosylation as well as poor ionization relative to the light chains.
In conclusion, the cardiac [beta]-myosin heavy chain gene is not the predominant gene for hypertrophic cardiomyopathy in Venezuelan patients.
These techniques identify isoforms of myosin heavy chain (MHC), the protein that classifies a fiber, present in the cells.
9,10) It was found that dynein molecule, especially from the outer arms, of protists consists of three heavy chains with three corresponding "heads", (11) while that of animals consists of only two heavy chains with two corresponding heads, (12) together with several intermediate chains and light chains.
Private idiotypes located on light and heavy chains of human myeloma proteins characterized by monoclonal antibodies.
Under the agreement, the licensed Harbour transgenic mice produce H2L2 IgG antibodies, comprising two heavy chains and two light chains, with fully human variable regions.
Sunder was rocking gently - typical behaviour by such an animal under stress - with all four legs shackled by heavy chains.
Last week when we visited he was in the dark of a windowless shed, rocking gently, legs shackled by heavy chains.
Normal immunoglobulins (Ig) consist of heavy chains (IgG, IgA, IgM, IgD, and IgE) and light chains (kappa or lambda).
Wearing sunglasses, a black TShirt with shiny, heavy chains around his neck, Tinchy, bobbed around Liverpool's O2 Academy 2 on the first night of his Rollercoaster tour.
Annie - Britain's last circus elephant - was secretly filmed being struck with a metal pitchfork, kicked in the face and body 48 times and shackled by heavy chains at the Bobby Roberts Super Circus.