heavy chain


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Related to heavy chain: light chain, heavy chain disease

chain

 [chān]
a collection of objects linked together in linear fashion, or end to end, as the assemblage of atoms or radicals in a chemical compound, or an assemblage of individual bacterial cells.
branched chain an open chain of atoms, usually carbon, with one or more side chains attached to it.
closed chain several atoms linked together so as to form a ring, which may be saturated, as in cyclopentane, or aromatic, as in benzene.
H chain (heavy chain) any of the large polypeptide chains of five classes that, paired with the L or light chains, make up the antibody molecule of an immunoglobulin; heavy chains bear the antigenic determinants that differentiate the classes of immunoglobulins. See also heavy chain disease.
J chain a polypeptide occurring in polymeric IgM and IgA molecules.
L chain (light chain) either of the two small polypeptide chains (molecular weight 22,000) that, when linked to H or heavy chains by disulfide bonds, make up the antibody molecule of an immunoglobulin monomer; they are of two types, kappa and lambda, which are unrelated to immunoglobulin class differences.
open chain a series of atoms united in a straight line; components of this series are related to methane.
chain reaction a chemical reaction that is self-propagating; each time a free radical is destroyed a new one is formed.
side chain a group of atoms attached to a larger chain or to a ring.

heav·y chain

a polypeptide chain a subunit of an immunoglobulin molecule, of high molecular weight, such as the γ, α, μ, δ, or ε chains, determining the immunoglobulin class and subclass. This chain also determines whether complement can be bound and whether the chain can pass through the placenta. There are two identical chains in each immunoglobulin.
Synonym(s): H chain

heavy chain

n.
The larger of the two types of polypeptide chains in immunoglobulins, consisting of an antigen-binding portion having a variable amino acid sequence, and a constant region that defines the antibody class.

heavy chain

a high-molecular-weight polypeptide that is part of an immunoglobulin molecule. Different types of heavy chains characterize the various categories of immunoglobulins (Igs), such as IgG and IgA.

heav·y chain

(hev'ē chān)
A polypeptide chain of high molecular weight determining the class and subclass of an immunoglobulin.

heavy chain

see IMMUNOGLOBULIN.

chain

a collection of objects linked together in linear fashion, or end to end, as the assemblage of atoms or radicals in a chemical compound, or an assemblage of individual bacterial cells.

chain binomial model
model of an outbreak of an infectious disease in which the outbreak is depicted as a series of steps with a binomial statement of the probability of an outcome at each step.
branched chain
an open chain of atoms, usually carbon, with one or more side chains attached to it.
heavy chain
any of the large polypeptide chains of five classes that, paired with the light chains, make up the antibody molecule. Heavy chains bear the antigenic determinants that differentiate the immunoglobulin classes. See also heavy-chain disease.
J chain
a polypeptide occurring in polymeric IgM and IgA molecules.
light chain
either of the two small polypeptide chains (molecular weight 22,000) that, when linked to heavy chains by disulfide bonds, make up the antibody molecule; they are of two types, kappa and lambda, which are unrelated to immunoglobulin class differences.
light chain disease
the overproduction of immunoglobulin light chain molecules by certain B cell tumors (plasmacytomas). See monoclonal gammopathy.
obstetric chain
used in obstetrics in cattle and horses to snare extremities and for traction. Made of rustproof metal with links designed not to kink or to jam. They have a loop link at each end to facilitate single-handed formation of a loop. The links are shaped so that the ring-grip handles used for traction will grip at any point and stay put with the strongest pull.
chain shank
a leather lead with a short section of chain at the proximal end. It can be placed over the horse's nose, through the mouth or across the upper gum for greater control.
side chain
a chain of atoms attached to a larger chain or to a ring.
stallion chain
strong chain, 1-2 ft (0.5 m) long, at the end of a solid lead. For leading a stallion with little chance of his biting through the lead.
chain termination method

heavy

having great weight.

heavy chain
see heavy chain.
heavy chain switch
see class switching.
heavy grain feeding
feeding of cereal grain feeds at levels in excess of conventional practice is frequently followed by carbohydrate engorgement, rumenitis and hepatic abscessation. Persistent feeding at levels less than those conducive to lactic acidosis is thought to contribute to the development of left displacement of the abomasum.
heavy horse breeds
heavy metals
lead, mercury, silver, zinc, copper, arsenic, iron.
heavy veal calves
fed on hard feed, weigh >400 lb (182 kg), aged >3 weeks. Called also western veal calves.
References in periodicals archive ?
Protein and mRNA levels of the myosin heavy chain isoforms Ibeta, IIa, IIx and IIb in type I and type II fibre-predominant rat skeletal muscles in response to chronic alcohol feeding.
2000) Lack of Coordinated changes in metabolic enzymnes and myosin heavy chain isoforms in regenerated muscles of trained rats.
After 10 days, the extract-treated cells were able to express a-actinin and myosin heavy chain, but not the other markers.
Mutation screening in dilated cardiomyopathy: prominent role of the beta myosin heavy chain gene.
Force-velocity relations and myosin heavy chain isoform compositions of skinned fibres from rat skeletal muscle.
The sea urchin sperm [alpha] heavy chain (OAD [alpha] family) and [beta] heavy chain (OAD [beta] family) correspond to the Chlamydomonas [gamma] heavy chain (ODA[gamma]) and [alpha] heavy chain (ODA[alpha], respectively, while Chlamydomonas [alpha] and [beta] (ODA[beta]) arose from a single gene by duplication at a certain point of evolution (both belong to the OAD [beta] family).
Three MAbs (3F2D8, 8F9A8 and 5F 19G11) recognize linear epitopes, while the remaining MAb (1F4C4) reacts with a conformational epitope located on heavy chain of all IgG subclasses.
The assay kit that was used, namely "antiserum against human immunoglobulin light chains", recognized ([kappa]) and lambda ([lambda]) light chains both free and bound to heavy chains in intact immunoglobulins.
mu] Heavy-Chain Disease: monoclonal cytoplasmic [mu] heavy chain +, B-cell antigen +, [CD5.
This prompted the authors, Hood and Talmage, to propose the possibility that 10,000 light chain genes, in combination with 10,000 heavy chain genes, could produce 100 million specificities.
For example, more than 25% of heavy chain drug shoppers indicate that they plan to buy more lipstick/lip gloss at chain drug stores in the next 12 months, while only 7% intend to buy more suntan products.
Their topics include therapeutic perspectives involving ferritin heavy chain FtH, race and ethnicity, new findings about cardiovascular dysfunction, and Parkinson's Disease as a perfect target for gene therapy.