heat-shock proteins


Also found in: Dictionary, Encyclopedia.
Related to heat-shock proteins: heat shock response

heat-shock proteins

A range of peptides that are well conserved throughout a wide range of organisms and are produced by the body in response to various stressors. They are found in high concentration in plaques of ATHEROSCLEROSIS and levels of heat-shock proteins in people who have suffered strokes and heart attacks, and women with breast cancer, are higher than in controls. Antibodies against bacterial HSP can cross-react with human HSP60 causing cytotoxic damage to endothelial cells stressed by FREE RADICALS or infection. Heat-shock proteins are also associated with oral ulcers and Behçet's disease. They are found in a variety of bacteria.
References in periodicals archive ?
Variation in the expression of Hsp70, the major heat-shock protein, and thermotolerance in larval and adult selection lines of Drosophila melanogaster.
Heat-shock proteins and molecular chaperones: implications for pathogenesis, diagnostics, and therapeutics.
Hsf1 activates this repair system by boosting the activity of heat-shock proteins.
Gene expression of heat-shock proteins (Hsp23, Hsp70 and Hsp90) during and after larval diapause in the blow fly Lucilia sericata.
Evolution of the [alpha]-crystallin/small heat-shock protein family.
When cells heat up, he explains, protective molecules called heat-shock proteins spring into action.
Organismal, ecological, and evolutionary aspects of heat-shock proteins and the stress response: Established conclusions and unresolved issues.
Heat-shock proteins from a number of mycobacterial species have been shown to generate Th1-type responses, airway inflammation, and airway hyperresponsiveness (32).
Activation of HSF and selective increase in heat-shock proteins by acute dexamethas one treatment.
Normally, heat-shock proteins protect other proteins inside a cell from being damaged by extreme heat or other stress.
Microbial cells in which heat-shock proteins are synthesized acquire additional thermal tolerance to a second heat challenge that would normally be lethal to them.