heat-shock proteins


Also found in: Dictionary, Encyclopedia.
Related to heat-shock proteins: heat shock response

heat-shock proteins

A range of peptides that are well conserved throughout a wide range of organisms and are produced by the body in response to various stressors. They are found in high concentration in plaques of ATHEROSCLEROSIS and levels of heat-shock proteins in people who have suffered strokes and heart attacks, and women with breast cancer, are higher than in controls. Antibodies against bacterial HSP can cross-react with human HSP60 causing cytotoxic damage to endothelial cells stressed by FREE RADICALS or infection. Heat-shock proteins are also associated with oral ulcers and Behçet's disease. They are found in a variety of bacteria.
References in periodicals archive ?
Autologous tumor-derived heat-shock protein peptide complex-96 (HSPPC-96) in patients with metastatic melanoma.
Variation in the expression of Hsp70, the major heat-shock protein, and thermotolerance in larval and adult selection lines of Drosophila melanogaster.
Molecular chaperones: towards a characterization of the heat-shock protein 70 family.
Hsf1 activates this repair system by boosting the activity of heat-shock proteins.
The markers attempt to identify and isolate a variety of cell growth factors, like IGF, and the lack of proteins associated with cell death or protein degradation, like caspases that trigger death or heat-shock proteins (HSPs) that start the processes for protein breakdown.
Arsenic is well known to induce heat-shock proteins (Del Razo et al.
In the receptors' quiescent state, they are covered by substances, called heat-shock proteins, that keep them in a state of readiness to bind to estrogen.
Bukrinsky and Zhao compare the functional similarities of Vpr and heat-shock proteins, and Pomerantz presents data to support the role of Vpr in neuroinvasion and neuropathogenesis.
Vierling (1997)Expression and native structure of cytosolic class II small heat-shock proteins.
The function of heat-shock proteins in stress tolerance, degradation and reactivation of damaged proteins.