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heat-labile |
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| coli strains from 430 patients were selected, and all were analyzed by a multiplex PCR (3) that detects the following pathogenic genes: heat-stable and heat-labile enterotoxins (st, lt) for ETEC, intimin (eaeA) and bundle-forming pilus (bfp) for EPEC, Shiga toxin 1 and 2 (stx1, stx2) and intimin (eaeA) for STEC, and invasion-associated loci (ia1) for EIEC. Aphios' virus inactivation process can be applied to immunoglobulins and wound healing biotherapeutics, human plasma used for blood transfusions, bone graft materials and other implantables, heat-labile and sensitive medical instrumentation, xenotransplantation products, animal sera used in the biotechnology industry, and recombinant therapeutics from mammalian cell culture and transgenic animals where a virus inactivation step is essential and necessary for the manufacture of safe products. Compared to the trace reaction of spotted fever group rickettsiae to rOmpB, a stronger, but still weak, reaction was detected to the heat-labile state of rOmpB of R. |
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