Discordance of global estimates by patients and their physicians in usual care of many rheumatic diseases: association with 5 scores on a multidimensional health assessment questionnaire (MDHAQ) that are not found on the health assessment questionnaire (HAQ).
The LITHE study also showed that patients who received either dose of ACTEMRA plus methotrexate showed significant improvement in physical function, compared with patients who received methotrexate plus placebo at Weeks 52 and 104, as measured by the mean area under the curve (AUC) of the Health Assessment Questionnaire Disability Index (HAQ-DI)1 change from baseline.
Patients with at least two comorbidities had longer disease duration, and they had more active disease as measured by parameters including the Disease Activity Score 28 and the Health Assessment Questionnaire.
These were the change from baseline in the health assessment questionnaire disability index (HAQ-DI), percentage of patients achieving at least a 50 percent improvement in signs and symptoms (ACR50) and percentage of patients with improved disease activity score in 28 joints (DAS28 remission) at week 24; P ?
While mortality risk was not significantly different among the treatment arms; mortality risk was higher for patients who were older at baseline, male, smokers, and those with poorer scores on a baseline health assessment questionnaire.