hazard grouping

hazard grouping

A 4-tier system for stratifying the risk of human disease after exposure to biological agents (pathogens):
HG1 agents
Unlikely to cause disease in immunocompetent hosts.

Example
Aspergillus spp.

HG2 agents
Pathogenic, but unlikely to spread to the community if the infection is appropriately managed or prophylactic measures are taken.

Example
Actinomyces, Clostridia spp, HSV, HPV, MRSA.

HG3 agents
Can cause severe disease and spread to the community, despite adequate management and/or prophylactic measures.

Example
HBV, HCV, HIV, SARS, Salmonella typhi, Mycobacterium tuberculosis, Brucella, Q fever, anthrax.

HG4 agents
Highly contagious, cause severe disease; there is no effective therapy.

Examples
Rabies, smallpox and viral haemorrhagic fevers (e.g., Ebola and Lassa).
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