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hard metal disease |
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hard metal disease, pneumoconiosis caused by inhalation of fine particles of cobalt, usually in conjunction with tungsten carbide. In early stages reversible hyperplasia and metaplasia of the bronchial epithelium are seen. Later, subacute alveolitis and then chronic interstitial fibrosis develop. Also called cobalt lung. How to thank TFD for its existence? Tell a friend about us, add a link to this page, add the site to iGoogle, or visit webmaster's page for free fun content. |
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The large case series of hard metal disease described byMoriyami and colleagues in their article provides an important source of clinico-pathologic data pertaining to a rare, but important interstitial lung disease (1). hard metal disease, is also symptomatic and does not concentrate on tungsten or cobalt levels. Adverse impact is caused by charged substitutions in positions [beta]55, [beta]56, [beta]B69, [beta]84, and [beta]85, namely, the exact same loci identified as genetic markers of CBD susceptibility as well as cobalt-lung hard metal disease. |
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