haptoglobin


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haptoglobin

 [hap´to-glo″bin]
a group of serum alpha2-globulin glycoproteins that bind free hemoglobin; three phenotypes, with differing abilities to bind hemoglobin, are distinguished electrophoretically.

hap·to·glo·bin (HP),

(hap'tō-glō'bin), [MIM*140100 & MIM*140210]
A group of α2-globulins in human serum, so called because of their ability to combine with hemoglobin, preventing loss in the urine; variant types form a polymorphic system, with α- and β-polypeptide chains controlled by separate genetic loci. Levels are decreased in hemolytic disorders and increased in inflammatory conditions or with tissue damage.
[G. haptō, to grasp, + hemoglobin]

haptoglobin

/hap·to·glo·bin/ (hap″to-glo´bin) a plasma glycoprotein with alpha electrophoretic mobility that irreversibly binds free hemoglobin, resulting in removal of the complex by the liver and preventing free hemoglobin from being lost in the urine; it has two major genetic variants, Hp 1 and Hp 2.

haptoglobin

(hăp′tə-glō′bĭn)
n.
A plasma protein that is a normal constituent of blood serum and functions in the binding of free hemoglobin in the bloodstream.

haptoglobin

[hap′tōglō′bin]
Etymology: Gk, haptein, to grasp; L, globus, ball
a plasma protein that irreversibly binds free hemoglobin and is removed by macrophages conserving iron. The quantity of haptoglobin is increased in certain chronic diseases and inflammatory disorders and is decreased or absent in hemolytic anemia. Normal adult findings range from 100 to 150 mg/dL. Compare transferrin. See also hemoglobinemia, hemoglobinuria.

haptoglobin

A protein in the circulation that migrates in the α2 portion of serum subjected to electrophoresis, a so-called acute phase reactant that ↑ in serum in acute inflammation or infection, stress, or necrosis Role Bind Hb released from RBCs undergoing hemolysis, preventing the accumulation of Hb in plasma; after iron has been removed, the haptoglobin-bound Hb is eliminated by the reticuloendothelial system.

hap·to·glo·bin

(hap'tō-glō'bin)
A group of α2-globulins in human serum, so called because of their ability to combine with hemoglobin; variant types form a polymorphic system, with α- and β-polypeptide chains controlled by separate genetic loci.
[G. haptō, to grasp, + hemoglobin]

haptoglobin

Alpha2 -globulin, a plasma protein that binds free haemoglobin to form a complex too large to pass out of the kidneys into the urine.

Haptoglobin

A blood protein made by the liver. Its main role is to save iron by attaching itself to any hemoglobin released from a red cell.

haptoglobin

a group of serum alpha2 globulin glycoproteins, produced by the liver, that bind free hemoglobin; important in acute phase reactions (response). The different types, genetically determined, are distinguished electrophoretically.
References in periodicals archive ?
1), ([double dagger]) 51 62 Reticulocyte count, G/L 61 (3-183), 16 60 (2-444), 25 LDH level, IU/L 777 (161-3,003), 24 803 (312-2,722), 28 Haptoglobin level, g/L 0.
Abnormal changes of plasma acute phase proteins in schizophrenia and the relation between schizophrenia and haptoglobin (Hp) gene.
That was suggested by the decrease of transferrin and haptoglobin concentrations observed in [NAT.
It should be noted that the linear haptoglobin polymers produced in Hp2-1 individuals differ considerably from both Hp2-2 and Hp1-1 in their molecular structure, and may also be functionally different.
The observed decrease in haptoglobin, prealbumin, and albumin in hepatic scarring and increase in IgG heavy constant chain, Ig [kappa]/[lambda] chain regions, and IgA heavy chain is consistent with previous studies (4, 33-35).
Clinical and in vitro studies have demonstrated that the genetic polymorphism of the abundant plasma protein haptoglobin (Hp) may play a role.
0%); lactate dehydrogenase, 2267 U/L (200-450 U/L); haptoglobin, <58 mg/L (160-2000 mg/L); folic acid, 9.
2] macroglobulin, haptoglobin, and apolipoprotein [A.
The report provides test volume and sales forecasts by country and market segment for the follow assays: C3 C4 Free Light Chains Haptoglobin IgA IgE Specific IgE Total IgG IgM Immunofixation Prealbumin Protein Electrophoresis During the next decade, the immunoprotein testing market will undergo significant transformation.
Because of the oxidative and toxic properties of the iron-containing heme in Hb, Hb is complexed by the plasma protein haptoglobin (Hp).
On postoperative day three, in addition to deteriorating renal function, blood analysis showed anaemia (haemoglobin 80 g/1) and intravascular haemolysis (serum haptoglobin lower than 0.
In the laboratory values checked on the third day, the determined laboratory values were CK-MB--427 U/L, Wbc--36700 cell/[micro]L, PNL % 93, erythrocyte sedimentation rate--62mm/h, fibrinogen--648 mg/dl, haptoglobin --356 mg/dl, seruloplasmin--67 ng/dl, CRP--15 mg/L.