hapten


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Related to hapten: complete antigen, Tolerogen

hapten

 [hap´ten]
a small molecule, not antigenic by itself, that can react with specific antibodies and elicit the formation of such antibodies when conjugated to a larger antigenic molecule, usually a protein, called in this context the carrier. Antibody production involves activation of B lymphocytes by the hapten and helper T cells by the carrier.

hap·ten

(hap'-ten),
A molecule that is incapable, by itself, of causing a cell-mediated or humoral immune response but can, however, combine with a larger antigenic molecule called a carrier. A hapten-carrier complex can stimulate antibody production and reactive T-cells.
See also: hapten inhibition of precipitation.
[G. haptō, to fasten, bind]

hapten

/hap·ten/ (hap´ten) partial antigen; a specific nonprotein substance which does not itself elicit antibody formation but does elicit the immune response when coupled with a carrier protein.hapten´ic

hapten

(hăp′tĕn′) also

haptene

(-tēn′)
n.
A small molecule that reacts with a specific antibody but cannot induce the formation of antibodies unless bound to a carrier protein or other large antigenic molecule.

hap·ten′ic adj.

hapten

[hap′tən]
Etymology: Gk, haptein, to grasp
a small molecule that acts as an antigen by combining with particular bonding sites on an antibody. By itself it cannot induce an immune response, but when bonded to a carrier protein may cause an immune response.

hap·ten

(hap'tĕn)
A molecule that is incapable, alone, of causing the production of antibodies but can, however, combine with a larger antigenic molecule called a carrier.
Synonym(s): incomplete antigen, partial antigen.
[G. haptō, to fasten, + -en, noun suffix]

hapten

An incomplete antigen that cannot, by itself, promote antibody formation but that can do so when conjugated to a protein. Most haptens are organic substances of low molecular weight. From the Greek haptein , to fasten.

hapten

a substance that is able to combine with specific antibodies but does not produce them unless attached to a large CARRIER MOLECULE.

hap·ten

(hap'tĕn)
A molecule that is incapable, alone, of causing the production of antibodies but can, however, combine with a larger antigenic molecule called a carrier.
Synonym(s): incomplete antigen, partial antigen.
[G. haptō, to fasten, + -en, noun suffix]

hapten (hap´tən),

n a nonproteinaceous substance that acts as an antigen by combining with particular bonding sites on an antibody. Unlike a true antigen, it does not induce the formation of antibodies. A hapten bonded to a carrier protein may induce an immune response. Also called
haptene.

hapten, haptene

a small-molecular-weight either inorganic or organic molecule that alone is not antigenic but which when linked to a carrier protein, e.g. albumin, is antigenic; the antibody so produced will react with the hapten alone.
References in periodicals archive ?
Since company inception, Hapten Sciences has pursued an aggressive and efficient development timeline.
2) The CC genotype results in lower PXR expression, and this may result in dysregulation of normal bile acid homeostasis as well as leading to higher levels of drug in the liver, thereby promoting hapten formation and immune injury.
The dogma that "small" organic molecules (that is, molecules of molecular weights of less than about 1000 Daltons) need to be presented as haptens bound to a macromolecular carrier (151) to be immunogenic may not always hold true (135), but in any case, morphine at least may bind to serum proteins (114) and numerous laboratory studies have demonstrated ready formation of immunoglobulin G and immunoglobulin M antibodies to protein-coupled opioids (152-164).
The use of a DNCB-Ethanoic acid compound to induce inflammation in the colons of rats resulted in test subjects whose symptoms, CMDI score and tissue pathological changes suggest the successful creation of an animal model of ulcerative colitis (according to a hapten induction mechanism with normal immune systems).
A fragment of a micro-organism may bind to a larger endogenous protein, producing a protein hapten complex which then becomes antigenic and an immune reaction against part of the protein is mounted; or a drug could cause this haptenisation and thus an autoimmune reaction (Bone 1999).
Bu konuda ileri surulen gorusler; virusun trombositlerle birleserek hapten etkisi gostermesi ve trombositlere antijenik ozellik kazandirmasi, kemik iliginde trombosit yapiminin baskilanmasi, splenomegali olan olgularda trombositlerin dalakta seketrasyonu, immun komplekslere bagli olarak trombositlerin yikilmasi seklinde sayilabilir.
A simple method for increasing hapten immunogenicity by a specific structural modification of the carrier[], J.
Drugs or their methobolites can act as a hapten after binding to the keratinocyte surface and initiate cytotoxic immunological attack.
Hapten hipotezine gore ilac proteinlere kovalan baglarla baglandiktan sonra immun sistemi uyarabilir.
ROT'nin olusturdugu DNA hasari, derideki kontakt duyarlanmada azalma, dendritik hucrelerin antijen sunabilme yetenegindeki bozulma, hapten spesifik supresor T lenfositlerin gelisimiyle dogru orantilidir (30).
When a drug acts as a hapten to induce thrombocytopenia, an antibody forms against: