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hapten

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hapten /hap·ten/ (hap´ten) partial antigen; a specific nonprotein substance which does not itself elicit antibody formation but does elicit the immune response when coupled with a carrier protein.hapten´ic
hap·ten (hptn)
n.
A substance that is capable of reacting with a specific antibody but cannot induce the formation of antibodies unless bound to a carrier protein or other molecule. Also called incomplete antigen, partial antigen.

hapten
[hap′tən]
Etymology: Gk, haptein, to grasp
a nonproteinaceous substance that acts as an antigen by combining with particular bonding sites on an antibody. Unlike a true antigen, it does not induce the formation of antibodies. A hapten bonded to a carrier protein may cause an immune response. Also called haptene [hap′tēn] .

hapten [hap´ten]
a small molecule, not antigenic by itself, that can react with specific antibodies and elicit the formation of such antibodies when conjugated to a larger antigenic molecule, usually a protein, called in this context the carrier. Antibody production involves activation of B lymphocytes by the hapten and helper T cells by the carrier.

hapten (hap´tn),
n a nonproteinaceous substance that acts as an antigen by combining with particular bonding sites on an antibody. Unlike a true antigen, it does not induce the formation of antibodies. A hapten bonded to a carrier protein may induce an immune response. Also called
haptene.

hapten, haptene
a small-molecular-weight either inorganic or organic molecule that alone is not antigenic but which when linked to a carrier protein, e.g. albumin, is antigenic; the antibody so produced will react with the hapten alone.


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Hapten hipotezine gore ilac proteinlere kovalan baglarla baglandiktan sonra immun sistemi uyarabilir.
1- Haptenler 2- Epidermal hucreler: keratinositler ve Langerhans hucreleri 3- CD4+T hucreleri 4- Reaktif hucreler: monositler, makrofajlar ve notrofiller Alerjenler dusuk molekul agirlikli (500-1000 dalton) maddeler olup hapten yapisindadirlar (9).
Epitopa ozgul baskilanma: Tetanoz ve difteri toksoidi gibi tasiyicilara karsi onceden gelismis antikor varliginda, bu tasiyicilar ile verilen hapten polisakkarid epitoplara karsi bagisiklik yanitinda azalma gorulur(6).
 
 
 
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