hapten


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Related to hapten: complete antigen, Tolerogen

hapten

 [hap´ten]
a small molecule, not antigenic by itself, that can react with specific antibodies and elicit the formation of such antibodies when conjugated to a larger antigenic molecule, usually a protein, called in this context the carrier. Antibody production involves activation of B lymphocytes by the hapten and helper T cells by the carrier.

hap·ten

(hap'-ten),
A molecule that is incapable, by itself, of causing a cell-mediated or humoral immune response but can, however, combine with a larger antigenic molecule called a carrier. A hapten-carrier complex can stimulate antibody production and reactive T-cells.
See also: hapten inhibition of precipitation.
[G. haptō, to fasten, bind]

hapten

/hap·ten/ (hap´ten) partial antigen; a specific nonprotein substance which does not itself elicit antibody formation but does elicit the immune response when coupled with a carrier protein.hapten´ic

hapten

(hăp′tĕn′) also

haptene

(-tēn′)
n.
A small molecule that reacts with a specific antibody but cannot induce the formation of antibodies unless bound to a carrier protein or other large antigenic molecule.

hap·ten′ic adj.

hapten

[hap′tən]
Etymology: Gk, haptein, to grasp
a small molecule that acts as an antigen by combining with particular bonding sites on an antibody. By itself it cannot induce an immune response, but when bonded to a carrier protein may cause an immune response.

hap·ten

(hap'tĕn)
A molecule that is incapable, alone, of causing the production of antibodies but can, however, combine with a larger antigenic molecule called a carrier.
Synonym(s): incomplete antigen, partial antigen.
[G. haptō, to fasten, + -en, noun suffix]

hapten

An incomplete antigen that cannot, by itself, promote antibody formation but that can do so when conjugated to a protein. Most haptens are organic substances of low molecular weight. From the Greek haptein , to fasten.

hapten

a substance that is able to combine with specific antibodies but does not produce them unless attached to a large CARRIER MOLECULE.

hap·ten

(hap'tĕn)
A molecule that is incapable, alone, of causing the production of antibodies but can, however, combine with a larger antigenic molecule called a carrier.
Synonym(s): incomplete antigen, partial antigen.
[G. haptō, to fasten, + -en, noun suffix]

hapten (hap´tən),

n a nonproteinaceous substance that acts as an antigen by combining with particular bonding sites on an antibody. Unlike a true antigen, it does not induce the formation of antibodies. A hapten bonded to a carrier protein may induce an immune response. Also called
haptene.

hapten, haptene

a small-molecular-weight either inorganic or organic molecule that alone is not antigenic but which when linked to a carrier protein, e.g. albumin, is antigenic; the antibody so produced will react with the hapten alone.
References in periodicals archive ?
Similar to Janda's antiheroin vaccine, haptens are bound to a protein carrier, spurring the immune system to create high levels of antibody to bind heroin and its metabolites in the blood and prevent it from crossing the blood-brain barrier.
3] have been observed in other animal models that used haptens to induce skin inflammation [38].
The hapten was also conjugated with bovine serum albumin (BSA) in a similar manner to the immobilized antigen [27-30].
Until now, haptens have been measurable only by use of competitive immunoassays because their limited molecular sizes impede simultaneous binding of 2 antibodies to 1 hapten molecule.
RXi Pharmaceuticals, a United States-based biotechnology company, has closed its exclusive global license agreement with United States- based Hapten Pharmaceuticals for the therapeutic use of Samcyprone.
Hapten Synthesis and Development of ELISAs for Detection of Endosulfan in Water and Soil.
Plea Not (Penicillium notatum) from Terra Medica is great for all staph and strep infections, as is the hapten Pleo San Staph.
Flucloxacillin binds covalently to selective lysine residues on albumin to form a hapten.
Janda, Investigating the Effects of a Hydrolytically Stable Hapten and a Thl Adjuvant on Heroin Vaccine Performance, 55 J.
Hapten synthesis and development of ELISAs for the detection of endosulfan in water and soil.
This vaccine consists of the hapten 3'-aminomethylnicotine that has been conjugated to Pseudomonas aeruginosa exoprotein, which was made nontoxic by deletion of an amino acid.
This study aimed at developing a method for the preparation of hapten and immunogen for producing polyclonal antibody specific to cypermethrin for the determination of insecticide residues in contaminated fruits and vegetables.