haplotype


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haplotype

 [hap´lo-tīp]
1. a set of alleles of a group of closely linked genes, such as the HLA complex, which are usually inherited as a unit, an individual inheriting a complete haplotype from each parent.
2. the genetic constitution of an individual at a set of linked genes.

hap·lo·type

(hap'lō-tīp),
1. The genetic constitution of an individual with respect to one member of a pair of allelic genes; individuals are of the same haplotype (but of different genotypes) if alike with respect to one allele of a pair but different with respect to the other allele of a pair.
2. In immunogenetics, that portion of the phenotype determined by a set of closely linked genes inherited from one parent (that is, genes located on one of the pair of chromosomes).
[haplo- + G. typos, impression, model]

haplotype

/hap·lo·type/ (-tīp) the group of alleles of linked genes, e.g., the HLA complex, contributed by either parent; the haploid genetic constitution contributed by either parent.

haplotype

(hăp′lə-tīp′)
n.
A set of alleles of different genes that are closely linked on one chromosome and are usually inherited as a unit.

hap·lo·type

(hap'lō-tīp)
1. The genetic constitution of an individual with respect to one member of a pair of allelic genes; individuals are of the same haplotype (but of different genotypes) if alike with respect to one allele of a pair but different with respect to the other allele of a pair.
2. immunogenetics That portion of the phenotype determined by a set of closely linked genes inherited from one parent (i.e., genes located on one of the pair of chromosomes). The human major histocompatability complex comprises 4 recognized loci (A, B, C, and D) for which there are more than 50 alleles. Similarly, the allotypic markers (antigens) of the immunoglobulin subclasses IgG1, IgG2, IgG3, and IgA2 occur in combinations and are inherited as units almost always unchanged in transmission; the alleles that control these various haploptypes are not linked to those controlling the antigens of the κ type L chains.
[haplo- + G. typos, impression, model]

haplotype

The entire set of allelic variants that may be found at any particular genetic location.

haplotype

see HLA SYSTEM.

Haplotype

A set of alleles (an alternative form of a gene that can occupy a particular place on a chromosome) of a group of closely linked genes which are usually inherited as a unit.

haplotype

the group of alleles of linked genes contributed by either parent; the haploid genetic constitution contributed by either parent.
References in periodicals archive ?
In order to analyze the most common PTGS2 haplotypes, different PR and 3'-UTR variants were generated by site-directed mutagenesis using overlap extension PCR (14).
The remaining 6 samples were haplotype G38, a common fur-farm haplotype with an Alaskan or north-Canadian origin (for example, Sacks and others 2011; Statham and others 2012).
Sublineages SL1 to SL3 are defined by the topology of haplotype network shown in Figure 2.
The presence of premature stop codons in some of the nad2 and coI sequences of the familial analysis is striking and is the strongest argument for nuclear pseudogenes, but pseudogenes in the nuclear genome would have to both occur at a low enough frequency for the male contribution to be unobservable within these data but also have undergone enough duplication to account for the observed haplotype diversity.
Haplotype h4, found in MV30 and LBP, was the most distinct, differing from the others at 20-23 positions.
Maternal plasma DNA sequencing data were interpreted with the parental haplotype information to deduce the mutational status of the fetus.
The haplotype H6 was more frequent than H7, in addition occurring in homozygous individuals.
i] represents the probability that a recipient has a haplotype i, p[D.