haploidentical

haploidentical

/hap·lo·iden·ti·cal/ (hap″lo-i-den´tĭ-k'l) sharing a haplotype; having the same alleles at a set of closely linked genes on one chromosome.
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This includes cord blood transplant, haploidentical transplant, and unrelated donors in order to provide to a greater number of patients access to this lifesaving therapy.
However, the use of haploidentical donor grafts is only feasible in conjunction with severe immunosuppression which renders the patient highly vulnerable to infections.
Ringden, Treatment of severe acute graft-versus-host disease with third party haploidentical mesenchymal stem cells, Lancet, 363, 1439-144 (2004).
Cellular and molecular basis of haploidentical hematopoietic stem cell transplantation in the successful treatment of high-risk leukemias: role of alloreactive NK cells.
Plans are under way for a four-year randomized trial for so-called haploidentical marrow or cord blood transplants in 380 patients to begin late this year or early next year.
This process expands on a recently described method that permits automated target cell detection and virtual enrichment, microdissection, and identification of the genomic origin of haploidentical single cells by means of DNA fingerprinting (10).
9) In light of the fact that the patient's donor was haploidentical, a perfect 10 out of 10 HLA match; it has also been shown that non-myeloablative therapies have shown decreased transplant-related mortality.
Kiadis reports ATIR has shown good clinical results in a Phase I/II study in patients who received haploidentical mismatched bone marrow transplantation from a family member donor.
The child, a girl who was born in January 2002, received an allogeneic haploidentical stem cell transplant from her father in May 2002 after her diagnosis of SCID.
Nadler has again demonstrated that he is a translational pioneer, and his work is now making breakthroughs in the fields of haploidentical stem cell transplantation and tumor immunity.