hantavirus pulmonary syndrome


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Related to hantavirus pulmonary syndrome: leptospirosis

hantavirus pulmonary syndrome

a febrile disease caused by several species of Hantavirus (Andes, Bayou, Black Creek Canal, New York, and Sin Nombre viruses) in North and South America and characterized by thrombocytopenia, leukocytosis, and capillary leakage in the lungs, with death due to shock and cardiac complications.

hantavirus pulmonary syndrome

a sometimes fatal febrile illness caused by a virus of the genus Hantavirus, characterized by variable respiratory symptoms followed by acute respiratory distress, sometimes progressing to respiratory failure.
An often fatal respiratory tract infection with massive acute pulmonary edema often at death caused by a hantavirus; the first cluster occurred in the Four Corners region of Southwestern US
Epidemiology Mean age 32, 61% women, 72% Native American
Case definition Unexplained bilateral interstitial infiltrates on chest films, arterial O2 saturation < 90%
Prodrome Fever, myalgia (100%), cough or shortness of breath (75%), GI symptoms, headache, tachycardia, tachypnea, hypotension
Lab Leukocytosis—± 26 x 109/L—often with myeloid precursors, increased haematocrit, thrombocytopaenia of ±64 x 109/L, increased PT, increased aPTT, increased LD, decreased serum protein, proteinuria
Prevention Vaccine is being developed

hantavirus pulmonary syndrome

An often fatal RTI caused by a hantavirus; the first cluster occurred in the Four Corners region of Southwestern US Epidemiology Mean age 32, 61% ♀, 72% Native American Case definition Unexplained bilateral interstitial infiltrates on chest film, arterial O2 saturation < 90% Prodrome Fever, myalgia-100%, cough or SOB-76%, GI Sx, headache, tachycardia, tachypnea, hypotension Lab Leukocytosis–± 26 x 109/L, often with myeloid precursors, ↑ Hct, thrombocytopenia of ±64 x 109/L, ↑ PT, ↑ aPTT, ↑ LD, ↓ serum protein, proteinuria Diagnosis Immunohistochemistry, Western blot, ELISA, IgM capture ELISA; massive acute pulmonary edema is common at death

Han·ta·vi·rus pul·mo·na·ry syn·drome

(hahn'tă-vī'rŭs pul'mŏ-nar-ē sin'drōm)
A febrile disease caused by several species of Hantavirus (Andes, Bayou, Black Creek Canal, New York, and Sin Nombre viruses) in North and South America and characterized by thrombocytopenia, leukocytosis, and capillary leakage in the lungs, with death due to shock and cardiac complications.

hantavirus pulmonary syndrome

Acute respiratory illness featuring a brief period of fever, muscle pains, headache, nausea and cough followed by severe shock and pulmonary oedema simulating the acute adult RESPIRATORY DISTRESS SYNDROME (ARDS). The mortality without specific treatment is 50–75 per cent but the drug ribavirin is effective. The disease is caused by a strain of hanta virus and was originally though to be acquired only from rodents. Human case-to-case infection has now been demonstrated.
References in periodicals archive ?
A household-based, case-control study of environmental factors associated with hantavirus pulmonary syndrome in the southwestern United States.
Clinicians should consider a diagnosis of hantavirus pulmonary syndrome in all persons with febrile illnesses that progress rapidly to respiratory insufficiency following rodent exposures in enclosed spaces.
Outbreak of Hantavirus pulmonary syndrome in the southwestern United States.
Hantavirus pulmonary syndrome in central Bolivia: relationships between reservoir hosts, habitats, and viral genotypes.
Hantavirus pulmonary syndrome (HPS) is an uncommon but severe disease that can occur after contact with an infected rodent or rodent-infested area.
Hantavirus pulmonary syndrome 2010 case definition [cited 2013 Jul 8].
The ecology and evolutionary history of an emergent disease: hantavirus pulmonary syndrome.
Hantavirus pulmonary syndrome in Panama: identification of novel hantaviruses and their likely reservoirs.
Hantavirus pulmonary syndrome (HPS) is a potentially fatal zoonosis caused by hantaviruses (family Bunyaviridae, genus Hantavirus) that are principally associated with members of the rodent family Cricetidae, more specifically, members of the subfamily Neotominae or Sigmodontinae (1,2).
In the Americas, hantavirus species that occur at low frequency are associated with the severe disease hantavirus pulmonary syndrome (HPS) (1,2), and species that occur at higher frequency are associated with milder disease (3-5).