The five most common fruquintinib treatment-related adverse events were hand-foot syndrome
, hypertension, dysphonia, proteinuria and AST elevation, which is similar to those reported in this class.
He tolerated treatment well with only minimal side effects, such as hand-foot syndrome
, for approximately 10 months after the diagnosis.
In the Phase II randomized discontinuation trial, the most common Grade 3 or 4 adverse events that participants experienced included fatigue, hand-foot syndrome
, hypertension, decreased appetite, nausea, and vomiting.
The most common side effects reported in patients treated with Stivarga include weakness or fatigue, loss of appetite, hand-foot syndrome
(also called palmar-plantar erythrodysesthesia), diarrhea, mouth sores (mucositis), weight loss, infection, high blood pressure, and changes in voice volume or quality (dysphonia).
Advancell has announced the initiation of a clinical phase IIb study of its treatment ATH008 for palmar-plantar erythrodysesthesia syndrome, or hand-foot syndrome
, a painful side effect of chemotherapy.
Grade 3/4 toxicities consisted of fatigue in 40% of patients, hand-foot syndrome
in 20%, and diarrhea in 20%.
Cutaneous reactions: A number of oral agents are highly linked to reactions such as skin rash and hand-foot syndrome
However, the patients on the drug showed a higher incidence of adverse events like anemia and hand-foot syndrome
as compared with those on the placebo.
nausea, vomiting, rash, alopecia, hand-foot syndrome
UFT, however, has the advantage of not inducing hand-foot syndrome
, which is typically seen for capecitabine.
A significant hand-foot syndrome
, featuring acral skin desquamation and tender erythema at pressure points, was also present.
Now on an oral form of chemotherapy, Shaffer suffers from chronic diarrhea and hand-foot syndrome
- a chemo side effect that turns her hands and feet bright red and causes the skin to crack and peel.