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hand-foot syndrome

   Also found in: Wikipedia 0.01 sec.
hand-foot syndrome
Sickle cell dactylitis Hematology A 'crisis' in sickle cell anemia caused by sludging of RBCs in vessels and characterized by symmetric infarction of the small bones of the hand and foot, periosteal neoosteogenesis, pain and swelling that may occur as early as age 18 months, often resolving spontaneously within 1-4 wks. See Sickle cell anemia.


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Hand-foot syndrome is a frequent side effect of capecitabine.
This HFSR, also observed with a number of other antiangiogenesis therapies, is distinct from the hand-foot syndrome often seen in patients receiving cytotoxic chemotherapy.
Key Words: sorafenib, sunitinib, multitargeted tyrosine kinase inhibitors (TKIs), renal cell carcinoma, hand-foot syndrome ********** Multiple mucocutaneous side effects have been described with the use of multitargeted tyrosine kinase inhibitors, including hand-foot syndrome, various rashes, pruritus, cheilitis, mucositis, eyelid edema, subungual splinter hemorrhages, hair depigmentation, alopecia, and dry skin.
 
 
 
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