hand-and-foot syndrome

hand-and-foot syn·drome

recurrent painful swelling of the hands and feet occurring in infants and young children with sickle cell anemia.
References in periodicals archive ?
The most common side effects are diarrhea, hand-and-foot syndrome, nausea, vomiting, anemia, sores in the mouth, abdominal pain, constipation, loss of or decrease in appetite, rash, dry or itchy skin, eye irritation, tiredness, weakness, dizziness, headache, and fever.