17) Furthermore, researchers have demonstrated that halofuginone
, which is a specific inhibitor of TGF-[beta]1 up-regulation, can prevent urethral fibrosis formation in rat urethra.
Topically applied halofuginone
(an alkaloid originally isolated from the plant Dichora febrifuga) an inhibitor of collagen typeI transcription has also been claimed to reduce peritendinous fibrous adhesions following tendon surgery .
Anticancer activity of halofuginone
in a preclinical model of osteosarcoma: inhibition of tumor growth and lung metastases," Oncotarget, vol.
2008) Prevention of muscle fibrosis and improvement in muscle performance in the mdx mouse by halofuginone
Scientists have known that this compound, called halofuginone
(a derivative of the febrifugine), can suppress parts of the immune system-but nobody knew exactly how.
Now Tracy Keller and colleagues at the Harvard School of Dental Medicine in Boston have found that halofuginone
- a chemical based on the roots' active ingredient - blocks immune reactions that can cause disease.
A number of theileriocidals including tetracyclines, buparvaquone and halofuginone
lactate have been used for the treatment of this disease (Radostits et al.
is derived from an alkaloid isolated from Dichroa febrifuga plant .
11 substances are concerned: Lasalocid sodium, Narasin, Salinomycin sodium, Monensin sodium, Semduramicin, Maduramicin, Robenidine, Decoquinate, Halofuginone
, Nicarbazin, and Diclazuril.
Scientists hope the compound, called halofuginone
, can be used to tackle conditions such as rheumatoid arthritis, multiple sclerosis, Type 1 diabetes, inflammatory bowel disease and psoriasis.
Field study of the efficacy of halofuginone
and decoquinate in the treatment of cryptosporidiosis in veal calves.
(in infected lambs and calves) and paromomycin sulfate (in infected goat kids) have been used experimentally for the treatment of cryptosporidiosis.